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Membrane Transporters and Channels in Health and Diseases

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 1409

Special Issue Editor


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Guest Editor
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Interests: metabolism; nutrition; proteins; colon; colitis; inflammation; carcinogenesis; microbiota; hemochromatosis; T cells; B cells; cytokines

Special Issue Information

Dear Colleagues,

Membrane transporters and channels emerge as key players orchestrating cellular functions. At the heart of molecular processes, the intricate mechanisms and regulatory functions of transporters and channels come into sharp focus. This collection of research explores their molecular intricacies, unveiling the profound implications for cellular homeostasis.

This Special Issue addresses the latest research advances in membrane transport proteins, and we sincerely welcome high-quality original research and review papers. Possible research themes include but are not limited to the following:

  • Regulatory mechanisms of drug transport proteins;
  • Ion channels and cellular excitability;
  • Membrane transport and metabolic disorders;
  • Aberrant transport in tumor cells;
  • Membrane channel studies in neurodegenerative diseases.

By bridging disciplines such as biochemistry, biophysics, and pharmacology, this Special Issue hopes to foster a deeper understanding of the roles played by membrane transporters and channels in health and diseases.

Dr. Sathish Sivaprakasam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • G-protein-coupled receptors
  • amino acid transporter
  • citrate transporter
  • ion channel
  • membrane protein
  • immune regulation

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Published Papers (1 paper)

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Research

19 pages, 6204 KiB  
Article
Age-Related Effects of Inhalational Anesthetics in B4galnt1-Null and Cuprizone-Treated Mice: Clinically Relevant Insights into Demyelinating Diseases
by Ozana Katarina Tot, Stefan Mrđenović, Vedrana Ivić, Robert Rončević, Jakov Milić, Barbara Viljetić and Marija Heffer
Curr. Issues Mol. Biol. 2024, 46(8), 8376-8394; https://doi.org/10.3390/cimb46080494 - 1 Aug 2024
Viewed by 1074
Abstract
Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and [...] Read more.
Anesthetics are essential agents that are frequently used in clinical practice to induce a reversible loss of consciousness and sensation by depressing the central nervous system. The inhalational anesthetics isoflurane and sevoflurane are preferred due to their rapid induction and recovery times and ease of administration. Despite their widespread use, the exact molecular mechanisms by which these anesthetics induce anesthesia are not yet fully understood. In this study, the age-dependent effects of inhalational anesthetics on two demyelination models were investigated: congenital (B4galnt1-null) and chemically induced (cuprizone). Various motor and cognitive tests were used to determine sensitivity to isoflurane and sevoflurane anesthesia. B4galnt1-null mice, which exhibit severe motor deficits due to defects in ganglioside synthesis, showed significant impairments in motor coordination and balance in all motor tests, which were exacerbated by both anesthetics. Cuprizone-treated mice, which mimic the demyelination in B4galnt1-null mice, also showed altered, age-dependent sensitivity to anesthesia. The study showed that older mice exhibited more pronounced deficits, with B4galnt1-null mice showing the greatest susceptibility to sevoflurane. These differential responses to anesthetics suggest that age and underlying myelin pathology significantly influence anesthetic effects. Full article
(This article belongs to the Special Issue Membrane Transporters and Channels in Health and Diseases)
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