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Innovations in Marine Biotechnology and Molecular Biology
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Innovations in Marine Biotechnology and Molecular Biology

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2367

Special Issue Editor

Prof. Dr. Huarong Guo

E-Mail Website
Guest Editor
1. Key Laboratory of Marine Genetics and Breeding (Ministry of Education), College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
2. Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education), Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
Interests: shrimp; gene delivery; gene editing; transgenic shrimp; cell culture

Special Issue Information

Dear Colleagues,

In comparison to terrestrial animals, marine biotechnology and marine molecular biology are not well developed. This includes, but is not limited to, in vitro long-term cell culture of marine animals, efficient gene transfer and expression tools, CRISPR/Cas9 gene editing technology, genetical manipulation and application of functional target genes with merit traits, etc. In this Special Issue, we seek articles and reviews that bring new insights, diverse perspectives, groundbreaking discoveries or innovations, and new tools or modified tools that can promote our understanding and application of marine biotechnology in marine animals, algae, and microorganisms.

We also want to thank Dr. Dongmei Wang for her contribution to and support for the proposal, promotion, processing, and development of this Special Issue.

Dr. Huarong Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine animal
  • marine algae
  • marine microorganism
  • marine biotechnology
  • molecular biology

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Published Papers (3 papers)

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Research

22 pages, 14869 KiB  
Article
Molecular Characterization and Feeding-Associated Expression Dynamics of the Period Gene Family in Channel Catfish (Ictalurus punctatus)
by Hongyan Liu, Shiyong Zhang, Xiaohui Chen, Minghua Wang, Liqiang Zhong, Yongqiang Duan, Bingjie Xie, Luyu Tang and Yi Cheng
Curr. Issues Mol. Biol. 2025, 47(6), 438; https://doi.org/10.3390/cimb47060438 - 9 Jun 2025
Viewed by 41
Abstract
Rhythms, regulated by core clock genes like the period (per) gene family, are crucial for maintaining physiological processes in animals. In teleost fish, including channel catfish (Ictalurus punctatus), these genes have evolved distinct functions. However, the evolutionary characteristics and [...] Read more.
Rhythms, regulated by core clock genes like the period (per) gene family, are crucial for maintaining physiological processes in animals. In teleost fish, including channel catfish (Ictalurus punctatus), these genes have evolved distinct functions. However, the evolutionary characteristics and functional roles of period genes, particularly in response to environmental cues such as feeding, remain unclear. This study aimed to investigate the evolutionary divergence and functional specialization of the period gene family in channel catfish, with a focus on feeding-induced rhythmicity. Four period genes, Ipper1b, Ipper2, Ipper2l, and Ipper3, were identified in channel catfish. Phylogenetic analysis revealed distinct evolutionary paths for these genes, with Ipper2l forming a separate clade from Ipper2. Tissue-specific expression analysis showed differential expression of period genes across tissues, with Ipper1b exhibiting the highest expression in the intestine and Ipper2 being predominantly expressed in the liver. Statistical analysis confirmed significant differences in the expression levels between tissues (p < 0.05), supporting the tissue-specific roles of these genes. Notably, under strict feeding schedules, we observed significant modulation of rhythmic expression in both the brain and liver, with a notable shift in the peak expression times and amplitude changes aligned with the feeding time. These results suggest that feeding serves as a critical Zeitgeber, entraining circadian rhythms in key tissues and potentially enhancing metabolic efficiency. These results demonstrated that feeding schedules play a key role in modulating circadian gene expression in channel catfish. This study provides insights into the evolutionary divergence and functional roles of the period gene family in channel catfish, showing how feeding schedules modulate circadian gene expression in the brain and liver. These findings have potential applications in optimizing feeding strategies for improving fish health and growth in aquaculture. Full article
(This article belongs to the Special Issue Innovations in Marine Biotechnology and Molecular Biology)
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16 pages, 3616 KiB  
Article
The Protective Effects of Perch Essence Against Muscle Atrophy in Cancer Cachexia and Cisplatin Treatment
by Shu-Lan Yeh, Pei-Yin Chen, Jiunn-Wang Liao, Ruo-Li Huang, Shu-Han Yu, Ling-Ni Chen, Mao-Hsiang Lee, Li-Wen Chen, Haw-Wen Chen, Ya-Chen Yang, Yu-Ling Wu and Kai-Li Liu
Curr. Issues Mol. Biol. 2025, 47(3), 152; https://doi.org/10.3390/cimb47030152 - 26 Feb 2025
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Abstract
Muscle atrophy, through several pathways including increased protein catabolism, leads to adverse effects in cachexia induced by cancer and chemotherapy. Perch essence (PE) is a perch extract rich in branched-chain amino acids and peptides. The present study initially investigated the effects of PE [...] Read more.
Muscle atrophy, through several pathways including increased protein catabolism, leads to adverse effects in cachexia induced by cancer and chemotherapy. Perch essence (PE) is a perch extract rich in branched-chain amino acids and peptides. The present study initially investigated the effects of PE supplementation on muscle atrophy in a mouse model of cancer cachexia induced by C26 cancer cells and compared these effects with those of tryptone. Compared with the tumor-only group, we found that PE supplementation significantly improved body weight, muscle mass, maximum limb grip strength (MLGS), and myosin heavy chain expression in the muscles of tumor-bearing mice. PE also significantly inhibited the expression of factors related to protein degradation, oxidative stress, and inflammation, while enhancing the expression of antioxidant enzymes in tumor-bearing mice. These effects of PE were associated with an increased expression of phosphorylated Akt and forkhead box protein O1, along with a reduced expression of phosphorylated nuclear factor-κB p65 in the muscles of tumor-bearing mice. Furthermore, PE similarly increased MLGS and attenuated muscle atrophy in mice exposed to cisplatin by inhibiting protein degradation. All the therapeutic effects of PE supplementation mentioned above were generally greater than those of tryptone supplementation. These results suggest the potential of PE in protecting against muscle atrophy induced by tumors or chemotherapy. Full article
(This article belongs to the Special Issue Innovations in Marine Biotechnology and Molecular Biology)
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21 pages, 22623 KiB  
Article
Molecular Characterization, Expression Analysis, and CRISPR/Cas9 Mediated Gene Disruption of Myogenic Regulatory Factor 4 (MRF4) in Nile Tilapia
by Zahid Parvez Sukhan, Yusin Cho, Shaharior Hossen, Doo Hyun Cho and Kang Hee Kho
Curr. Issues Mol. Biol. 2024, 46(12), 13725-13745; https://doi.org/10.3390/cimb46120820 - 4 Dec 2024
Viewed by 1113
Abstract
Myogenic regulator factors (MRFs) are essential for skeletal muscle development in vertebrates, including fish. This study aimed to characterize the role of myogenic regulatory factor 4 (MRF4) in muscle development in Nile tilapia by cloning NT-MRF4 from muscle tissues. To explore [...] Read more.
Myogenic regulator factors (MRFs) are essential for skeletal muscle development in vertebrates, including fish. This study aimed to characterize the role of myogenic regulatory factor 4 (MRF4) in muscle development in Nile tilapia by cloning NT-MRF4 from muscle tissues. To explore the function of NT-MRF4, CRISPR/Cas9 gene editing was employed. The NT-MRF4 cDNA was 1146 bp long and had encoded 225 amino acids, featuring a myogenic basic domain, a helix-loop-helix domain, and a nuclear localization signal. NT-MRF4 mRNA was exclusively expressed in adult muscle tissues, with expression also observed during embryonic and larval stages. Food-deprived Nile tilapia exhibited significantly lower NT-MRF4 mRNA levels than the controls while re-feeding markedly increased expression. The CRISPR/Cas9 gene editing of NT-MRF4 successfully generated two types of gene disruption, leading to a frame-shift mutation in the NT-MRF4 protein. Expression analysis of MRF and MEF2 genes in gene-edited (GE) Nile tilapia revealed that MyoG expressions nearly doubled compared to wild-type (WT) fish, suggesting that MyoG compensates for the loss of MRF4 function. Additionally, MEF2b, MEF2d, and MEF2a expressions significantly increased in GE Nile tilapia, supporting continued muscle development. Overall, these findings suggest that NT-MRF4 regulates muscle development, while MyoG may compensate for its inactivation to sustain normal muscle growth. Full article
(This article belongs to the Special Issue Innovations in Marine Biotechnology and Molecular Biology)
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