Cellular and Molecular Mechanisms of EpiIepsy
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 113
Special Issue Editor
2. Department of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA
Interests: developmental epilepsy; the relationship between epilepsy and autism; bone comorbidities in epilepsy
Special Issue Information
Dear Colleagues,
Epilepsy is a complex neurological disorder characterized by recurrent seizures arising from disruptions in molecular and cellular processes that regulate neuronal excitability and network stability. This Special Issue seeks original research and reviews that explore cellular and molecular mechanisms underlying epilepsy across various developmental stages and etiologies. We welcome studies on neuronal hyperexcitability, neuroinflammation, synaptic and circuit dysfunction, ion channel regulation, glial signaling, metabolic alterations, and gene–environment interactions that contribute to epileptogenesis and seizure propagation.
Contributions examining genetic, developmental, and acquired causes of epilepsy, such as models of early-life seizures, cortical malformations, and neurodevelopmental disorders, are particularly encouraged. We also invite authors to submit work investigating molecular pathways involved in seizure-induced plasticity, neurodegeneration, and the impact of cognitive and neuropsychiatric comorbidities. Contributions employing innovative experimental approaches such as single-cell and spatial transcriptomics, advanced imaging, electrophysiology, connectomics, and translational biomarker discovery are also welcome.
By integrating findings from molecular, cellular, and systems-level studies, this Special Issue aims to highlight emerging mechanisms that drive epileptogenesis and identify potential targets for therapeutic intervention. We hope that these contributions will collectively deepen our mechanistic understanding of epilepsy and support the development of more precise and effective strategies for prevention, diagnosis, and treatment.
Dr. Joaquin N. Lugo
Guest Editor
Manuscript Submission Information
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Keywords
- pathophysiology
- molecular mechanism
- circuit
- ion channels
- comorbidities
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