Cellular and Molecular Mechanisms of Epilepsy
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 334
Editor
2. Department of Psychology and Neuroscience, Baylor University, Waco, TX 76798, USA
Interests: developmental epilepsy; the relationship between epilepsy and autism; bone comorbidities in epilepsy
Special Issue Information
Dear Colleagues,
Epilepsy is a complex neurological disorder characterized by recurrent seizures arising from disruptions in molecular and cellular processes that regulate neuronal excitability and network stability. This Special Issue seeks original research and reviews that explore cellular and molecular mechanisms underlying epilepsy across various developmental stages and etiologies. We welcome studies on neuronal hyperexcitability, neuroinflammation, synaptic and circuit dysfunction, ion channel regulation, glial signaling, metabolic alterations, and gene–environment interactions that contribute to epileptogenesis and seizure propagation.
Contributions examining genetic, developmental, and acquired causes of epilepsy, such as models of early-life seizures, cortical malformations, and neurodevelopmental disorders, are particularly encouraged. We also invite authors to submit work investigating molecular pathways involved in seizure-induced plasticity, neurodegeneration, and the impact of cognitive and neuropsychiatric comorbidities. Contributions employing innovative experimental approaches such as single-cell and spatial transcriptomics, advanced imaging, electrophysiology, connectomics, and translational biomarker discovery are also welcome.
By integrating findings from molecular, cellular, and systems-level studies, this Special Issue aims to highlight emerging mechanisms that drive epileptogenesis and identify potential targets for therapeutic intervention. We hope that these contributions will collectively deepen our mechanistic understanding of epilepsy and support the development of more precise and effective strategies for prevention, diagnosis, and treatment.
Dr. Joaquin N. Lugo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pathophysiology
- molecular mechanism
- circuit
- ion channels
- comorbidities
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
