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Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials
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Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1220

Special Issue Editors

Dr. Maria Maddalena Marrapodi

E-Mail Website
Guest Editor
Department of Woman, Child and General and Specialist Surgery, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy
Interests: temporomandibular disorders; orofacial pain; artificial intelligence; pediatric dentistry; oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Valentina Belli

E-Mail Website
Guest Editor
Department of Precision Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80131 Naples, Italy
Interests: COVID-19; health applications; telemedicine; dentistry; temporomandibular disorders; colorectal cancer; drug resistance; molecular biology; 3D organoid cultures

Special Issue Information

Dear Colleagues,

We are pleased to announce a new Special Issue titled “Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials”. The field of dentistry is witnessing significant advancements through the application of molecular biology techniques. These innovations are shaping the future of diagnostic methods, therapeutic approaches, and biomaterial development within oral health care. Molecular research is unveiling new insights into oral diseases, the oral microbiome, tissue regeneration, and biomimetic materials, which offer promising solutions for enhanced dental restorations, periodontal treatments, and implantology. This Special Issue will focus on the intersection of molecular biology and dentistry, with an emphasis on topics such as regenerative dentistry, gene therapy for oral conditions, the role of molecular pathways in dental diseases, and the development of bioactive materials for dental applications. We invite researchers and clinicians to contribute original research articles, reviews, short communications, case series, and case reports that explore the molecular aspects of dentistry, helping to bridge the gap between molecular biology and clinical practice for better patient outcomes.

Dr. Maria Maddalena Marrapodi
Dr. Valentina Belli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral microbiome
  • tissue regeneration
  • biomimetic materials

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Published Papers (1 paper)

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Research

10 pages, 3028 KiB  
Article
Vitamin D and LL-37 in Serum and Saliva: Insights into Oral Immunity
by Sotiria Davidopoulou, Kali Makedou, Areti Kourti, Ioanna Gkeka, Panagiotis Karakostas, Maria Pikilidou, Kosmas Tolidis and Sotirios Kalfas
Curr. Issues Mol. Biol. 2025, 47(2), 102; https://doi.org/10.3390/cimb47020102 - 6 Feb 2025
Viewed by 798
Abstract
(1) Background: In recent years, there has been a growing interest in understanding the innate immunity of the mouth, particularly the mechanisms through which vitamin D influences oral health. Researchers have increasingly focused on the association between vitamin D and the antimicrobial peptide [...] Read more.
(1) Background: In recent years, there has been a growing interest in understanding the innate immunity of the mouth, particularly the mechanisms through which vitamin D influences oral health. Researchers have increasingly focused on the association between vitamin D and the antimicrobial peptide LL-37 since the CAMP gene, responsible for encoding the LL-37 peptide, is a direct target of both vitamin D and its receptor (vitamin D receptor, VDR). This study aimed to explore the correlation between the 25-hydroxyvitamin D (25(OH)D) levels and the concentration of the LL-37 peptide in both serum and saliva. The objective was to compare the serum concentrations of 25(OH)D and ll-37 with those in saliva and to access the correlations between the two compounds. (2) Methods: Serum and whole saliva samples were collected from 72 healthy adults (mean age 28.68 ± 8.35). The levels of 25(OH)D and LL-37 were assessed in both the saliva and serum samples using commercially available enzyme-linked immunosorbent assay (ELISA) kits. (3) Results: The 25(OH)D levels in the serum (median 5.92 ng/mL, min–max 2.7–10.4 ng/mL) correlated with the LL-37 serum levels (62 ng/mL, min–max 18–378 ng/mL; Pearson’s r 0.328, p = 0.005). Additionally, the 25(OH)D levels in saliva (median 1.16 ng/mL, min–max 0.54–2.12 ng/mL) strongly correlated with the LL-37 salivary levels (median 44 ng/mL, min–max 6.5–205 ng/mL; Pearson’s r 0.667, p < 0.001). The 25(OH)D salivary levels demonstrated a robust correlation with the LL-37 salivary levels. (4) Conclusions: This discovery emphasizes the complex interplay between vitamin D and LL-37 and lay the groundwork for the further exploration of vitamin D’s role in oral immune function. Full article
(This article belongs to the Special Issue Molecular Biology in Dentistry: Innovations in Diagnosis, Treatment, and Biomaterials)
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