Electrochemical Immunosensors and Aptasensors

Dear Colleagues,

The possibility to integrate biorecognition elements into electrochemical detection systems has opened the way to a new class of powerful analytical devices named electrochemical (EC) biosensors. The first EC biosensors have employed enzymes as recognition element, however this has limited their application to redox enzymes and their natural or artificial redox substrates or inhibitors. The widening towards non-electroactive analytes was later possible thanks to the development of affinity sensors in which specific interactions between biomolecules are exploited for developing highly selective and sensitive biosensors. Presently, the combination of the exceptional molecular recognition capabilities of antibodies and aptamers with the sensitivity, low cost, practicality of use and handiness of electrochemical devices is leading to an impressive development of EC immunosensors and aptasensors, potentially suitable to detect a wide range of analytes, mainly (but not only) of a proteic nature, following a path that is moving side by side with the most recent advances in proteomics. Interestingly, together with continuous improvements and refinements in EC immunosensors based on the use of labels, intrinsically electroactive or able to interact with electroactive molecules, a new generation of label-free sensors is being developed.

The aim of this Special Issue of Chemosensors is take stock of the state of the art and identify prospects for EC immuno- and aptasensors, both labeled and label-free. Emphasis will be placed on analytical applications for the rapid detection of markers of diseases (e.g., cancer or heart attack), for toxicological and environmental control, for food safety and cultural heritage diagnostics.

Prof. Dr. Paolo Ugo
Prof. Dr. Ligia Moretto
Guest Editors

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