New Advances in Immunomodulation Using Biomaterials

Dear Colleagues,

Immunomodulatory biomaterials and devices have emerged as one of the most powerful frontiers in biomedical science. These biomaterials and devices enable control over immune responses and integrate principles of materials science, immunology, and engineering. The specific function of these platforms can be designed to present biological signals to recruit or reprogram immune cells and create microenvironments that direct tissue repair or enhance therapeutic efficacy. Over the last decade, the field has expanded rapidly from immune-instructive hydrogels and nanoparticle delivery systems to advanced scaffolds and engineered matrices that actively engage immune pathways.

However, fundamental challenges remain in understanding how material properties, such as mechanics, biocompatibility, degradability, surface chemistry, and ligand presentation, shape immune cell behavior and host responses. Deciphering these interactions is key to designing next-generation biomaterials that can achieve selective immunomodulation, minimize adverse reactions, and promote durable therapeutic outcomes.

For this Special Issue on Immunomodulation Using Biomaterials, we invite original research articles and reviews that advance our understanding of how biomaterials can be used to modulate immune function across diverse applications such as solid tumor treatment, cardiovascular diseases, tissue repair and regeneration, infectious diseases, etc.

This Special Issue will highlight studies that reveal how biomaterials can be engineered to harness or modulate immunity, with the goal of advancing next-generation therapies that are safer and more effective.

We look forward to receiving your contributions to this exciting and rapidly evolving field.

Prof. Dr. Gundula Schulze-Tanzil
Dr. Vaishali Inamdar
Guest Editors

Manuscript Submission Information

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