Transcriptional Regulatory Mechanisms in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 26589

Special Issue Editor
Interests: epigenetics; DNA methylation; transcriptional control; gene regulation; drug repurposing; neural stem cells; neurodevelopmental disorders; medulloblastoma brain tumor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gene regulatory mechanisms determine the expression state of each gene in a cell-type-specific and organ-dependent manner that are tightly controlled during development. Such regulatory mechanisms can act at the level of transcription, post-transcription, translation, and post-translation. Transcriptional regulation includes certain epigenetic mechanisms involving methylation and modification of DNA and RNA molecules, histone PTMs, action of non-coding RNAs, chromatin remodeling, nucleosome positioning, as well as interaction of trans-acting factors with cis-regulatory elements.
Transcriptional control is important for the proper process of embryonic development, organogenesis, and stem cell differentiation, with key roles in keeping our body in a health state. Accordingly, mis-regulation of transcriptional gene regulation leads to human disease.
The aim of this Special Issue is to serve as an overview platform for the latest discoveries in transcriptional gene regulation in development and disease, covering both original research and review articles. Post-transcriptional studies that involve the mechanistic basis of transcript turnover and/or transcript stability are also welcome. Studies that connect cellular function and signaling molecules to transcriptional gene regulation in development, health, and disease, as well as studies that report on the generation of novel model systems for transcriptional reporter assays are also welcome for submission.
Prof. Dr. Mojgan Rastegar
Guest Editor
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Keywords
- transcriptional regulation
- chromatin remodeling
- epigenetic modifications
- cis-regulatory elements
- trans-acting factors
- nucleosome positioning
- DNA–protein complexes
- health and disease
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