Special Issue "Molecular Basis of Osteoclast Differentiation and Activation"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 November 2020).
2. Department of Medicine, Weill Cornell Medicine, New York, NT 10021, USA
Interests: osteoimmunology; osteoclasts; metabolism; epigenetics; osteoporosis; avascular necrosis
As the only cells that can efficiently resorb bone, osteoclasts play a crucial role in maintaining bone health, differentiating from myeloid lineage precursor cells under the influence of a variety of cytokines and local factors. Chief among these are the macrophage colony stimulating factor (M-CSF) and receptor activator of NF-kB ligand (RANKL), which initiates osteoclast differentiation and serves as a critical factor for osteoclastogenesis and osteoclast activity. Over the past few decades following the initial discovery of RANKL, multiple signals that contribute to the differentiation and activity of osteoclasts have been identified. These complicated signaling networks provide multilayer regulations of osteoclasts; achieving a better understanding of the mechanisms involved in such networks can lead to the development of new therapeutic strategies to prevent or halt the pathogenesis of bone erosion, as well as suffering from its debilitating effects.
Thus, this special issue aims to provide an expansive overview of the intricate interplay between RANKL and the various signals that drive osteoclast differentiation and activity under physiological conditions. This issue also examines how these integrations can be modified under pathological conditions. With further discussion of the novel aspects of regulatory mechanisms that underlie osteoclast differentiation and function, I hope the research community can find value in our pursuit to broaden current knowledge of the spectrum of therapeutic targets that regulate osteoclasts in various disease settings.
Dr. Kyung Hyun Park-Min
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- Osteoclast precursor cells
- Signaling pathways
- Bone resorption