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The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function

by Robin Park 1,†, Shreya Madhavaram 1,† and Jong Dae Ji 2,*
MetroWest Medical Center/Tufts University School of Medicine, Framingham, MA 01702, USA
Department of Rheumatology, College of Medicine, Korea University, Seoul 02841, Korea
Author to whom correspondence should be addressed.
Robin Park and Shreya Madhavaram contributed equally to this work as first authors.
Cells 2020, 9(10), 2294;
Received: 23 September 2020 / Revised: 11 October 2020 / Accepted: 13 October 2020 / Published: 14 October 2020
(This article belongs to the Special Issue Molecular Basis of Osteoclast Differentiation and Activation)
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in bone remodeling through altering the interplay between bone-forming osteoblasts and bone-resorbing osteoclasts. While effects of AhR signaling in osteoblasts are well understood, the role and mechanism of AhR signaling in regulating osteoclastogenesis is not widely understood. AhR, when binding with exogenous ligands (environmental pollutants such as polycylic aryl hydrocarbon (PAH), dioxins) or endogenous ligand indoxyl-sulfate (IS), has dual functions that are mediated by the nature of the binding ligand, binding time, and specific pathways of distinct ligands. In this review, AhR is discussed with a focus on (i) the role of AhR in osteoclast differentiation and function and (ii) the mechanisms of AhR signaling in inhibiting or promoting osteoclastogenesis. These findings facilitate an understanding of the role of AhR in the functional regulation of osteoclasts and in osteoclast-induced bone destructive conditions such as rheumatoid arthritis and cancer. View Full-Text
Keywords: aryl-hydrocarbon receptor; osteoclastogenesis; bone remodeling; cytochrome P450 aryl-hydrocarbon receptor; osteoclastogenesis; bone remodeling; cytochrome P450
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Park, R.; Madhavaram, S.; Ji, J.D. The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function. Cells 2020, 9, 2294.

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