Cellular and Molecular Pathophysiology of Vascular Proliferative Diseases

Dear Colleagues,

Excessive cellular proliferation contributes to the pathobiology of vascular obstructive diseases (e.g., atherosclerosis, in-stent restenosis, transplant vasculopathy, vessel bypass graft failure, and pulmonary vascular diseases). Remodeling of the injured vessel, endothelium dysfunction, proliferation and migration of vascular smooth muscle cells (VSMC), and accumulation of extracellular matrix proteins are the main traits of these diseases.

Current advances in the study of pathogenesis have revealed that vascular proliferative diseases involve a combination of multiple causative factors (genomic, epigenomic, and environmental factors), which consequentially trigger signaling cascades of downstream effects, resulting in complex and heterogeneous phenotypes. Therefore, investigating the mechanism pathways underlying vascular dysfunction and remodeling can help design the potential key targets and find the most effective treatment. The main aim of this Topical Collection is to publish cutting-edge research using cutting-edge tools and technologies that can significantly advance the understanding of vascular diseases and transform future therapies.

Dr. Lahouaria Hadri
Collection Editor

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