Mitochondrial Metabolism in Cancer Prevention and Treatment
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 542
Special Issue Editor
Interests: mitochondrial metabolism in cancer prevention and treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
All forms of life share a common indispensable need for energy. The requirement of energy is necessary for an organism not only to survive but also to thrive. The metabolic activities in normal animal cells rely predominately on mitochondrial oxidative phosphorylation for energy generation in the form of ATP. On the contrary, cancer cells predominately rely on glycolysis rather than oxidative phosphorylation. It is long believed that impairment of mitochondrial oxidative phosphorylation is the cause of this glycolytic phenotype observed in cancers. However, studies in cancer metabolism have revealed that mitochondrial function in many cancers is intact. It has also been observed that cancers utilize various forms of metabolism. The various metabolic phenotypes are employed by cancer cells have a common purpose, to balance macromolecular biosynthesis, cellular reducing power, and sufficient ATP production to support rapid proliferation and accompanied survival threat characteristic of these aberrant cells. These metabolic pathways are attractive targets for possible therapeutic interventions and currently, research is underway to meet this end.
Dr. Yunfeng Zhao
Guest Editor
Manuscript Submission Information
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Keywords
- Oxidative phosphorylation
- ATP
- Oncology
- Cancer prevention
- Cancer therapy
- Biosynthesis
- Metabolic reprogramming
