Special Issue "DNA Repair, Genome Stability/Diversity, and Oxidative Stress and Aging, from Bacteria to Human Cells: A Themed Issue in Honor of Prof. Miroslav Radman"
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 30197
Interests: DNA double strand breaks repair; replication stress; homologous recombination; non-homologous end-joining; genetic rearrangement
Special Issues, Collections and Topics in MDPI journals
Interests: genome evolvability; DNA repair; DNA replication; mutation rates; homologous recombination; stress responses; bacterial adaptive evolution; resistance and persistence to antibiotics
Miroslav Radman is a French-Croatian geneticist and molecular biologist. He is recognized for his groundbreaking work on the molecular mechanisms of DNA repair, recombination, and mutation as well as their impact on biological evolution and human health. His most recognized discoveries are the following: the SOS response to DNA damage, particularly in relation to the genesis of mutations in bacteria; the DNA repair endonuclease III which is the first DNA damage N-glycosylase discovered; the mutagenic translesion DNA synthesis; the mismatch repair system which is the key genetic editing system that assures fidelity of DNA replication and recombination and generates genetic barriers between closely related species; the mechanism of nucleotide selection by DNA polymerases; the role of mutator mutants in the adaptive evolution of bacteria and their resistance to antibiotics; the direct real-time visualization of horizontal gene transfer and of detection of emerging mutation (replication fidelity) in single live bacterial cells; and the protection of proteins against oxidative damage as the basis of the resistance to radiation and desiccation of the highly radiation-resistant bacterium Deinococcus radiodurans, among others.
Miroslav Radman was born in Split, Croatia. He graduated in biology from the University of Zagreb, Croatia. In 1969, he received his PhD degree in molecular biology from the Free University of Brussels, Belgium. After working as a postdoctoral researcher, first with Raymond Devoret (1969-70) at the Centre national de la recherche scientifique (CNRS) at Gif-sur-Yvette, France, and then with Matthew Meselson at Harvard University, Cambridge, MA, USA (1970-73). It is during his time at Harvard, that Miroslav Radman made his first major discovery: the SOS system. Afterwards, he became, in 1972, an associate professor of molecular genetics at the Free University of Brussels. He moved to France in 1983 to become research director at the CNRS where he founded the Laboratory of Mutagenesis at the Jacques Monod Institute in Paris. From 1989 to 1990, he was a visiting Professor at the National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. In 1998, he became professor of cell biology at the Medical School of the University of Paris-5, where he directed the INSERM Research Unit "Molecular genetics and evolutionary medicine." He retired in 2013 as exceptional class professor emeritus, moving shortly afterwards to his native Split. There he founded, in 2004, the private and not-for-profit Mediterranean Institute for Life Sciences (MedILS) to study the biology of aging and age-related diseases. During his career, he has published over 200 research and review articles in the areas of DNA repair, DNA replication, mutagenesis, genetic recombination, evolution, microbiology, cancer research, protein oxidation and aging, that have been cited over 10,000 times. Additionally, he is the author of 2 books of scientific popularization about his recent work on the field of aging.
Miroslav Radman is a member of several international clubs and academies. He was elected to EMBO, the Croatian Academy of Sciences and Arts, the French Academy of Science, the World Academy of Arts and Sciences, the European Academy of Science, the European Academy of Microbiology, the American Academy of Arts and Sciences and the US National Academy of Science. Over his career, Miroslav Radman has received a dozen major national and international scientific awards, notably the Antoine Lacassagne Award for the discovery of the SOS system, and the Grand Prix Richard Lounsbery, a joint award by the French and US National Academies, for the discovery of mismatch repair as a genetic barrier between related species. Furthermore, he was knighted by the Presidents of Croatia and France for his overall contributions to the field of science. His participation and delivery of over 40 keynote, introductory, and closing talks at international congresses highlight his international recognition. For example, he was invited as speaker to both the New York and London-Cambridge celebrations for the 50th anniversary of the DNA structure, which is an acknowledgement of the impact of his ideas and research on modern genetics.
Miroslav Radman’s scientific achievements clearly reveal a highly innovative, creative, and daring thinker and scientist who is totally unconstrained by established dogmata. Described by some as the “enfant terrible” of science, Miroslav Radman’s work continues to revolutionize the world of science.
Dr. Bernard S. Lopez
Dr. Ivan Matic
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- DNA repair
- Homologous Recombination
- Genome instability
- Reactive oxygen species
- Molecular Evolution
- Eukaryotic cells