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Review

The Ultimate (Mis)match: When DNA Meets RNA

1
Institut Jacques Monod, Université de Paris, CNRS, F-75006 Paris, France
2
Department of Genetics & Development, Columbia University Irving Medical Center, New York, NY 10032, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Bernard S. Lopez and Ivan Matic
Cells 2021, 10(6), 1433; https://doi.org/10.3390/cells10061433
Received: 12 May 2021 / Revised: 4 June 2021 / Accepted: 5 June 2021 / Published: 8 June 2021
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity. Strikingly, different enzymatic activities classically involved in genome maintenance contribute to their generation, their processing into genotoxic or repair intermediates, or their removal. Here we review how this substrate promiscuity can account for the detrimental and beneficial impacts of RNA insertions during genome metabolism. We summarize how in vivo and in vitro experiments support the contribution of DNA polymerases and homologous recombination proteins in the formation of RNA-containing structures, and we discuss the role of DNA repair enzymes in their removal. The diversity of pathways that are thus affected by RNA insertions likely reflects the ancestral function of RNA molecules in genome maintenance and transmission. View Full-Text
Keywords: DNA repair; genetic recombination; genetic stability; transcription; RNA; ribonucleotide; DNA:RNA hybrid; R-loop DNA repair; genetic recombination; genetic stability; transcription; RNA; ribonucleotide; DNA:RNA hybrid; R-loop
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MDPI and ACS Style

Palancade, B.; Rothstein, R. The Ultimate (Mis)match: When DNA Meets RNA. Cells 2021, 10, 1433. https://doi.org/10.3390/cells10061433

AMA Style

Palancade B, Rothstein R. The Ultimate (Mis)match: When DNA Meets RNA. Cells. 2021; 10(6):1433. https://doi.org/10.3390/cells10061433

Chicago/Turabian Style

Palancade, Benoit, and Rodney Rothstein. 2021. "The Ultimate (Mis)match: When DNA Meets RNA" Cells 10, no. 6: 1433. https://doi.org/10.3390/cells10061433

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