Special Issue "Protective Mechanisms Against DNA Replication Stress"
Deadline for manuscript submissions: closed (31 January 2020).
Interests: DNA replication; replication stress; DNA damage tolerance; genome instability
Interests: genome stability and instability; DNA double strand breaks; DNA integrity
Replication stress has emerged as one of the primary challenges our cells face when replicating their genome. Replication forks routinely encounter hindrances that stall the progression of DNA polymerases, such as abasic sites and some oxidized bases, higher-order structures that are difficult to replicate, and actively transcribed regions. Moreover, imbalanced nucleotide pools also affect replication dynamics. Replication fork stalling generates single-stranded DNA that triggers protective pathways that either enable the replication fork to restart or protect nascent DNA from degradation. Failure in these mechanisms leads to replisome disassembly and collapse into double-strand breaks. During mitosis, unresolved replication stress gives rise to anaphase bridges, fragile sites, and supernumerary centrosomes that lead to multipolar spindles and aneuploidy. Replication stress is therefore a major driving force of genome instability and has been proposed to be involved in early stages of cancer and senescence. Inhibitors of critical replication stress signaling cascades have gained clinical importance in recent years, as has our understanding of how replicative exhaustion accelerates aging and replicative DNA damage induces inflammation.
Prof. Anja Katrin Bielinsky
Dr. Bernard Lopez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
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- ATR/CHK1 signaling
- endogenous stress
- environmental stressors
- replication fork stalling
- collapse and restart
- endonucleolytic cleavage
- mitotic catastrophe
- replication stress-induced inflammation
- transcription/replication conflict
- nucleotide pool imbalance
- cell cycle checkpoints
- fragile sites
- anaphase bridges
- supernumerary centrosomes