Special Issue "G-Protein Coupled Receptors in Cancer"
Deadline for manuscript submissions: closed (15 January 2022).
G-protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. Signaling by heterotrimeric G-proteins begins when ligand binding to the GPCR triggers a conformational change promoting proximity of the GEF domain and the GDP-bound heterotrimeric G-protein. GTP exchange liberates the a-subunit from the bg-subunits and initiates signal transduction. G-protein inactivation occurs when GTP hydrolyses to GDP in the a-subunit (promoted by RGS proteins) and the bg-subunits re-associate. The pathway may also be inhibited by phosphorylation of the GPCR by protein kinases, the subsequent binding of arrestin proteins, and internalization of the receptor through clathrin-coated pits. Despite mediating a cornucopia of physiological processes, the role of GPCRs in tumor biology is underappreciated. GPCRs, their ligands, and downstream effectors significantly regulate tumor growth and metastasis but influence tumor and stromal cells alike. The normal physiological functions of GPCRs are often hijacked by malignant cells to promote cell survival and proliferation, immune cell evasion, local and distant invasion, and recruitment of blood vessels.
This Special Issue of Cells invites both original research and review articles that examine the role of GPCRs, their G-protein targets and their regulatory apparatus (RGSs, GRKs) in tumorigenesis (including the role of point mutations, gene overexpression, and epigenetic promoter silencing), and stromal and immune responses in the tumor milieu. We will also discuss the unique opportunities for targeting GPCRs for therapeutic gain in cancers without current therapy and those refractory to current approaches.
Dr. Anthony Ashton
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.