Calcium Signaling in Health and Diseases

Dear Colleagues,

Ca²⁺ signaling is involved in a myriad of cellular functions, including cell death, cell survival, autophagy, muscle contraction, and memory formation. Abnormalities in intracellular Ca²⁺ signaling have been shown to lead to defects in several organellar functions, resulting in cellular dysfunction and potential cell death. As such, it comes as no surprise that in numerous pathologies, dysregulated Ca²⁺ signaling plays a critical, early role in disease onset. Understanding how the cellular Ca²⁺ toolkit is organized and how it can be modulated is thus critical to further increase understanding of how pathologies arise and can be treated. Given the Ca²⁺ toolkit, its central role in many cellular functions provides a challenging yet interesting potential drug target pool to explore.

This Special Issue aims to highlight recent findings on how Ca2+ signaling regulates cellular functions, with the main focus being on how organellar function is affected in both physiological and pathophysiological conditions.

Dr. Tim Vervliet
Dr. Dhanendra Tomar
Guest Editors

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