Special Issue "Mitochondrial Calcium Signaling, Mitochondrial Dynamics, and Mitophagy"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 15 December 2019.

Special Issue Editor

Dr. Dhanendra Tomar
E-Mail Website
Guest Editor
Center for Translational Medicine, Lewis Katz School of Medicine of Temple University, Philadelphia, Pennsylvania, USA
Interests: Mitochondria, Calcium, Post-translational modifications, Autophagy

Special Issue Information

Dear Colleagues,

Mitochondria are the central hub for cellular metabolism and provide energy to perform all cellular functions. Besides their critical role in bioenergetics, mitochondria are the site of cell death signaling events. Mitochondrial signaling is determined by the spatiotemporal regulation of mitochondrial shape, size, and location. The functional mitochondrial pool in the cell is maintained through the processes of biogenesis, fusion-fission, movement, and mitophagy, collectively known as mitochondrial dynamics. Mitochondrial homeostasis is regulated by various metabolic inputs like nutrient availability and hormonal regulation, which also regulate Ca2+ dynamics. In response to various pathophysiological signals, mitochondria exhibit early alterations in their shape and function, which, may be explained by mitochondrial fission, fusion, structural remodeling, and mitochondrial permeability transition pore (MPTP) regulated swelling. Upon physiological stimulation, cytosolic Ca2+ content is increased and taken up into the mitochondrial matrix via the Mitochondrial Calcium Uniporter Channel (mtCU). The mtCU mediated Ca2+ sequestration is essential to increase the activity of the TCA-cycle which fuels the electron transport chain to generate the ATP. Although Ca2+ signals shape mitochondrial bioenergetic output, sustained elevation of cytosolic Ca2+ drives excessive Ca2+ uptake which is a prerequisite for the opening of MPTP, mitochondrial swelling, and plasma membrane rupture and necrotic cell death.

The current Special Issue welcomes original research articles and reviews covering many aspects of mitochondrial biology. These include, but not limited to, mitochondrial biogenesis, fission/fusion, mitochondrial structural changes, mitochondrial trafficking, mitophagy, and mitochondrial Ca2+ signaling. We look forward to your contributions.

Dr. Dhanendra Tomar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mitochondria
  • Mitochondrial Calcium
  • Mitochondrial dynamics
  • Mitochondrial biogenesis
  • Fission/fusion
  • Calcium
  • Mitochondrial trafficking
  • Mitophagy
  • MCU
  • MPTP
  • Bioenergetics

Published Papers

This special issue is now open for submission.
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