Gene Engineering in Stem Cells for Drug Discovery and Therapeutic
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5306
Special Issue Editor
Interests: stem cells; biomarkers; genomics; proteomics; therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gene engineering technologies from viral vector-mediated to protein-based editing such as ZFN, TALENs, and CRISPR/Cas systems have been improved significantly. These technologies with stem cells have facilitated drug discovery and have resulted in the development of promising curative therapies for many intractable diseases. They can efficiently correct genetic errors; however, these technologies have limitations, such as off-target effects and possible safety issues, which need to be considered when employing these techniques in humans and animals. Significant efforts have been made to overcome these limitations and to accelerate the clinical implementation of these technologies.
In this way, the recent technological advancements in gene engineering and their applications in stem cells are developing to enable the efficient discovery of drugs and treatment of intractable diseases.
The main relevant topics for this Special Issue are:
- Precise gene editing techniques
- Safe and efficient therapeutics development
- Application of gene engineering platform in drug discovery
- Novel techniques in gene engineering
- Preclinical and clinical studies, etc.
Prof. Dr. Bonghee Lee
Guest Editor
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Keywords
- stem cells
- gene editing
- CRISPR-Cas
- TALEN
- drug discovery
- therapeutics development
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