Special Issue "The Role of Granulocytes in Immune Response"
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 3161
Interests: mitochondria; bioenergetics; cell death; inflammation
Interests: neutrophils; phagocytosis; reactive oxygen species (ROS); leukotrienes; swarming
Granulocytes are cells in the innate immune system characterized by the presence of specific granules in their cytoplasm. Granulocytes originate from pluripotent hematopoietic stem cells residing in the bone marrow through the myeloid differentiation arm. Multiple intermediate cell types are involved in this differentiation process, including myeloblasts and promyelocytes. All myeloblastic granulocytes are polymorphonuclear and are referred to as polymorphonuclear leukocytes (PMN, PML, or PMNL). The most abundant of the granulocytes are neutrophils, whose main function is to attack bacterial pathogens. Other cell types include eosinophils, basophils, and mast cells, which are primarily involved in allergic reactions. Granulocytes orchestrate the inflammatory process, an integral protective response against infection and injury.
This Special Issue focuses on the role of granulocytes as a component of the innate immune system in health and disease. We aim to cover different areas of research with a particular emphasis on the formation of extracellular traps (NETs) and the collective behavior of neutrophils (swarming). We also hope to attract research on the role of mitochondria in granulocyte function.
The title of the Special Issue is provisional and subject to change based on contributions from the authors.
Both comprehensive reviews and original articles are welcome. We look forward to your contributions.
Prof. Dr. Boris Chernyak
Prof. Dr. Galina F. Sud’ina
Dr. Maria A. Chelombitko
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