Pulmonary Hypertension - Cellular and Molecular Changes in the Lung and in the Right Ventricle

Dear Colleagues, 

Pulmonary hypertension (PH) is a severe disease characterized by sustained elevated pulmonary arterial pressures leading to right ventricular hypertrophy, right heart failure, and patient death. Since the currently available PH treatments improve patients’ quality of life and prolong their survival but fail to reverse the disease, new and efficient treatments are urgently needed. The key pathophysiological mechanisms of PH involve pulmonary arterial remodeling, inflammation, and altered reactivity, but all the cellular and molecular changes in the lung contributing to these alterations remain unknown. Gaining a better understanding of these changes may help us to highlight new potential therapeutic targets, undoubtedly leading to new perspectives in the treatment of PH. Another current challenge in PH is developing a strategy that would also be able to decrease/delay the development of right heart failure, which is often responsible for the death of PH patients. Gaining a better understanding of the right ventricular cellular and molecular changes associated with PH would also allow us to highlight new potential therapeutic targets. The aim of this Special Issue, entitled “Pulmonary hypertension – cellular and molecular changes in the lung and in the right ventricle”, is therefore to welcome both original papers and comprehensive review papers exploring the cellular and molecular changes in the lung and/or right ventricle during pulmonary hypertension, which may lead to opening new and exciting therapeutic perspectives on this devastating disease.  

We look forward to receiving your contributions. 

Prof. Dr. Véronique C. Freund-Michel
Guest Editor

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