New Discoveries of Protein Structure in Virus

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".

Deadline for manuscript submissions: closed (30 January 2022) | Viewed by 3902

Special Issue Editor


E-Mail Website
Guest Editor
Experimental and Applied Microbiology Lab., Universidad de Panamá, Campus Octavio Méndez Pereira, 4, Chitré, Panamá
Interests: structural biology; X-Ray crystallography; virus-host interactions

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to provide an overview of the latest findings in the field of viral protein structure. Viruses have simple genomes with a reduced number of genes that code for structural proteins, that is, those that form the capsid, and non-structural proteins such as polymerases or others that play regulatory or accessory roles. Thus, their life cycle mostly relies on the host cellular machinery. Viruses use a myriad of strategies that allow them to infect their host cells, replicate their genetic material, and sequester any factor from the host to ensure their propagation. A better understanding of these mechanisms is of great importance to develop new therapeutical strategies to fight these pathogens. In this sense, structural studies have always been of great importance since they provide high-resolution information that allows the rational design of drugs to combat viral infections.

This Special Issue of Cells therefore invites review articles and original research papers covering the viral protein structure research field. Topics will cover novel viral protein structures, viral-host protein interactions, viral protein regulation, drug design or capsid assembly, from a structural point of view.

Dr. Jordi Querol-Audi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viruses
  • protein structure
  • virus-host interactions
  • structure-based drug design
  • viral polymerases
  • viral life cycle regulation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 3704 KiB  
Article
Monitoring SARS-CoV-2 Surrogate TGEV Individual Virions Structure Survival under Harsh Physicochemical Environments
by Miguel Cantero, Diego Carlero, Francisco Javier Chichón, Jaime Martín-Benito and Pedro José De Pablo
Cells 2022, 11(11), 1759; https://doi.org/10.3390/cells11111759 - 27 May 2022
Cited by 18 | Viewed by 3445
Abstract
Effective airborne transmission of coronaviruses via liquid microdroplets requires a virion structure that must withstand harsh environmental conditions. Due to the demanding biosafety requirements for the study of human respiratory viruses, it is important to develop surrogate models to facilitate their investigation. Here [...] Read more.
Effective airborne transmission of coronaviruses via liquid microdroplets requires a virion structure that must withstand harsh environmental conditions. Due to the demanding biosafety requirements for the study of human respiratory viruses, it is important to develop surrogate models to facilitate their investigation. Here we explore the mechanical properties and nanostructure of transmissible gastroenteritis virus (TGEV) virions in liquid milieu and their response to different chemical agents commonly used as biocides. Our data provide two-fold results on virus stability: First, while particles with larger size and lower packing fraction kept their morphology intact after successive mechanical aggressions, smaller viruses with higher packing fraction showed conspicuous evidence of structural damage and content release. Second, monitoring the structure of single TGEV particles in the presence of detergent and alcohol in real time revealed the stages of gradual degradation of the virus structure in situ. These data suggest that detergent is three orders of magnitude more efficient than alcohol in destabilizing TGEV virus particles, paving the way for optimizing hygienic protocols for viruses with similar structure, such as SARS-CoV-2. Full article
(This article belongs to the Special Issue New Discoveries of Protein Structure in Virus)
Show Figures

Figure 1

Back to TopTop