Peroxisome Biogenesis and Protein Targeting Mechanisms

Dear Colleagues,

Peroxisomes are dynamic organelles that play a central role in lipid metabolism and cellular redox homeostasis. These so-called `multi-purpose’ organelles can undergo a context-dependent metamorphosis in number, size, shape, and function. Specialized forms, which are grouped as a microbody family, have been described as glyoxysomes of plants and certain fungi, glycosomes of parasitic protists like trypanosomes and Woronin bodies in filamentous fungi.

The biogenesis of peroxisomes can be categorized into five sub-networks that facilitate the key aspects of the development of functional peroxisomes: formation of the peroxisomal membrane, the targeting of peroxisomal matrix enzymes, peroxisomal fission, the inheritance of peroxisomes as well as the generation of contact sites to other organelles.

The important physiologic role of peroxisomes in health and disease is highlighted by the occurrence of peroxisomal disorders in humans. The regulation of peroxisomal biogenesis is also linked to age-associated diseases and the molecular process of aging as well as their function as a critical subcellular signaling hub in immune response and inflammation. Moreover, the control of peroxisomal function as a direct regulatory link to peroxisomal degradation via pexophagy is part of current research.

Therefore, this Special Issue aims to provide a platform for researchers around the world to communicate their latest findings and views on the targeting of peroxisomal proteins and low molecular weight factors in the multifaceted context of peroxisomal biogenesis.

Dr. Harald W. Platta
Guest Editor

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