Mineralized Tissues Repair and Regeneration

Dear Colleagues,

Mineralized tissues are hierarchically organized and are temporally and spatially heterogeneous due to continuous (re)modeling. Their mechanical properties depend on macro- and micro-architecture, as well as on material characteristics at the micro-nanoscale. This is particularly important for the understanding of the structure–function relationship in normal, ageing, and diseased bone and for predicting fracture risk—a prerequisite for prevalence and treatment of bone fragility.

Tooth loss is a global health problem representing a burden to society and economy. It affects an individual’s capacity for biting, chewing, smiling, speaking, and psychosocial wellbeing. Complete loss of natural teeth is widespread, particularly affecting older people. Dental caries, periodontal disease, and genetic disorders are major causes of tooth loss. Regenerative dentistry is an emerging field that challenges modern dentistry to improve dental research and translate scientific knowledge into new future clinical treatments.

This Special Issue is focused on the physiological processes of repair and regeneration of mineralized tissues with particular interest in the cellular mechanisms and/or paracrine effects involved in bone and mineralized dental tissues healing during aging/diseases or after injury, infections, and pharmacological or surgical procedures. It will also cover all tissues undergoing a natural or induced mineralization or calcification process under physiological or pathological conditions as well as in diagnostic and therapeutic contexts. Additionally, we are interested in the understanding of the proangiogenic, antimicrobial/bacterial, osteoinductive, osteoconductive, and mechanical effects exerted by therapeutics or different procedures. This Special Issue will cover histology, surgery, biomaterials, cell therapy, and tissue engineering, but also ex vivo/in vitro cell biology experimental models, and in vivo and clinic experimentations.

Prof. Dr. Roberta Di Pietro
Dr. Florelle Gindraux
Guest Editors

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