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Cells
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Mineralized Tissues Repair and Regeneration 2.0
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Mineralized Tissues Repair and Regeneration 2.0

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (10 October 2023) | Viewed by 8593

Special Issue Editors

Prof. Dr. Roberta Di Pietro

E-Mail Website
Guest Editor
1. Department of Medicine and Aging Sciences, Section of Biomorphology, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
2. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Interests: pancreas adenocarcinoma; hematological malignancies; lymphoma; CREB; TRAIL; apoptosis; caspase enzymes; extracellular vesicles; transmission electron microscopy
Special Issues, Collections and Topics in MDPI journals
Dr. Florelle Gindraux

E-Mail Website
Guest Editor
1. Service de Chirurgie Orthopédique, Traumatologique et Plastique, CHU Besançon, F-25000 Besançon, France
2. Service de Chirurgie Pédiatrique, CHU Besançon, F-25000 Besançon, France
3. Laboratoire de Nanomédecine, Imagerie, Thérapeutique EA 4662, Université Bourgogne Franche-Comté, F-25000 Besançon, France
Interests: advanced therapy medicinal products; regenerative medicine; tissue engineering; adult and perinatal (placenta) mesenchymal stromal cells; perinatal derivates; fetal membranes (amnion and chorion); foreign body membranes: induced membrane and periprosthetic capsules; bone substitutes; biomaterials; medical devices
Special Issues, Collections and Topics in MDPI journals
Dr. Céline Klein

E-Mail Website
Guest Editor
CHU Amiens Picardie, 80480 Salouel, France
Interests: fracture; bone and tissue regeneration; skeletal disorders

Special Issue Information

Dear Colleagues,

Mineralized tissues are hierarchically organized, and temporally and spatially heterogeneous due to continuous (re)modeling. Their mechanical properties depend on macro- and micro-architecture, as well as on material characteristics at the micro-nanoscale. This is particularly important for the understanding of the structure–function relationship in normal, ageing, and diseased bone, and for predicting fracture risk—a prerequisite for the prevalence and treatment of bone fragility.

Tooth loss is a global health problem representing a burden to society and economy. It affects an individual’s capacity for biting, chewing, smiling, speaking, and psychosocial wellbeing. The complete loss of natural teeth is widespread, particularly affecting older people. Dental caries, periodontal disease, and genetic disorders are major causes of tooth loss. Regenerative dentistry is an emerging field that challenges modern dentistry to improve dental research and translate the scientific knowledge into new and future clinical treatments.

This Special Issue is focused on the physiological processes of repair and regeneration of mineralized tissues, with particular interest in the cellular mechanisms and/or paracrine effects involved in bone and mineralized dental tissue healing during ageing/diseases, or after injury, infections, pharmacological, or surgical procedures. Additionally, we are interested in the understanding of the proangiogenic, anti-microbial/bacterial, osteoinductive, osteoconductive, and mechanical effects exerted by therapeutics or different procedures. This Special Issue will cover histology, surgery, biomaterials, cell therapy, and tissue engineering, as well as ex vivo/in vitro cell biology experimental models.

Prof. Dr. Roberta Di Pietro
Dr. Florelle Gindraux
Dr. Céline Klein
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone
  • tooth
  • repair
  • regeneration
  • tissue engineering
  • biomaterials
  • histology
  • imaging techniques
  • experimental models

Related Special Issue

Published Papers (3 papers)

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Editorial

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6 pages, 262 KiB  
Editorial
Questions about Using the Induced Membrane Technique to Manage Cases of Congenital Tibial Pseudarthrosis
by Céline Klein, Florelle Gindraux, Alain-Charles Masquelet, Romuald Mentaverri and Richard Gouron
Cells 2023, 12(14), 1918; https://doi.org/10.3390/cells12141918 - 24 Jul 2023
Viewed by 855
Abstract
The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results [...] Read more.
The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results of the induced membrane technique in NF1-deficient patients with CPT and in an animal model of CPT. Furthermore, we discuss the hypotheses used to explain inconsistent outcomes for the induced membrane technique in CPT–especially when associated with NF1. Full article
(This article belongs to the Special Issue Mineralized Tissues Repair and Regeneration 2.0)

Research

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18 pages, 7583 KiB  
Article
One Stage Masquelets Technique: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats
by Nicolas Söhling, Myriam Heilani, Charlotte Fremdling, Alexander Schaible, Katrin Schröder, Jan C. Brune, Volker Eras, Christoph Nau, Ingo Marzi, Dirk Henrich and René D. Verboket
Cells 2023, 12(9), 1289; https://doi.org/10.3390/cells12091289 - 30 Apr 2023
Cited by 2 | Viewed by 1191
Abstract
The classic two-stage masquelet technique is an effective procedure for the treatment of large bone defects. Our group recently showed that one surgery could be saved by using a decellularized dermis membrane (DCD, Epiflex, DIZG). In addition, studies with bone substitute materials for [...] Read more.
The classic two-stage masquelet technique is an effective procedure for the treatment of large bone defects. Our group recently showed that one surgery could be saved by using a decellularized dermis membrane (DCD, Epiflex, DIZG). In addition, studies with bone substitute materials for defect filling show that it also appears possible to dispense with the removal of syngeneic cancellous bone (SCB), which is fraught with complications. The focus of this work was to clarify whether the SCB can be replaced by the granular demineralized bone matrix (g-DBM) or fibrous demineralized bone matrix (f-DBM) demineralized bone matrix and whether the colonization of the DCD and/or the DBM defect filling with bone marrow mononuclear cells (BMC) can lead to improved bone healing. In 100 Sprague Dawley rats, a critical femoral bone defect 5 mm in length was stabilized with a plate and then encased in DCD. Subsequently, the defect was filled with SCB (control), g-DBM, or f-DBM, with or without BMC. After 8 weeks, the femurs were harvested and subjected to histological, radiological, and biomechanical analysis. The analyses showed the incipient bony bridging of the defect zone in both groups for g-DBM and f-DBM. Stability and bone formation were not affected compared to the control group. The addition of BMCs showed no further improvement in bone healing. In conclusion, DBM offers a new perspective on defect filling; however, the addition of BMC did not lead to better results. Full article
(This article belongs to the Special Issue Mineralized Tissues Repair and Regeneration 2.0)
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Review

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31 pages, 5710 KiB  
Review
A Brief Review of Bone Cell Function and Importance
by Veronika Šromová, Dinara Sobola and Pavel Kaspar
Cells 2023, 12(21), 2576; https://doi.org/10.3390/cells12212576 - 05 Nov 2023
Cited by 3 | Viewed by 6070
Abstract
This review focuses on understanding the macroscopic and microscopic characteristics of bone tissue and reviews current knowledge of its physiology. It explores how these features intricately collaborate to maintain the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, which plays a pivotal [...] Read more.
This review focuses on understanding the macroscopic and microscopic characteristics of bone tissue and reviews current knowledge of its physiology. It explores how these features intricately collaborate to maintain the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption, which plays a pivotal role in shaping not only our physical framework but also overall health. In this work, a comprehensive exploration of microscopic and macroscopic features of bone tissue is presented. Full article
(This article belongs to the Special Issue Mineralized Tissues Repair and Regeneration 2.0)
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