Caenorhabditis elegans: Cell Biology and Physiology
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 8695
Special Issue Editors
Interests: neuronal circuit; motor neuron disease; electrophysiology; molecular biology; Caenorhabditis elegans
Special Issue Information
Dear Colleagues,
Even though a nematode worm is significantly anatomically simpler than a human, Caenorhabditis elegans does share essential similarities at the molecular level with human and mammals, making it a good candidate for a model organism. Compared to the other model animals, Caenorhabditis elegans is easy to feed, manipulate, and maintain. In particular, research into Caenorhabditis elegans is cost effective and has obvious advantages in many aspects. Caenorhabditis elegans is used to study neural development and the function of the neuronal circuit. It is well suited for this application due to the availability of a comprehensive connectivity map and only 302 neurons and ~7000 synapses. Its transparent body makes it possible to observe the fate and probed fluorescence of individual cells using simple microscopy, or more advanced techniques such as super-resolution microscopy and EM. Worms have a very short life cycle and grow in large numbers, allowing for a large genetic screen for mutants that are critical for the life process. Caenorhabditis elegans has also been broadly used in drug screening for human neuropsychiatric disorders. Moreover, Caenorhabditis elegans is a highly important model to study ageing processes because the organism passes through several distinct phases of life, which can be observed physiologically and genetically throughout their 2-week lifespan. Hence, this Special Issue is expected to provide a collection of cutting-edge research and systemic reviews in a diverse array of topics, including physiology, neurobiology, cell development, behavior, aging, ecology, gene regulation, and the disease model by using the model animal Caenorhabditis elegans.
Topics of interests include, but are not limited to, the following:
- The molecular mechanism for synapse and neuronal development.
- The neural circuit mechanism for behavior.
- Transcriptional and post-transcriptional gene regulation.
- Intracellular signaling, organelles, and cell polarity.
- Regeneration and degeneration.
- Epigenetics and genome organization.
- The metabolism, stress, lifespan, and aging.
- The advanced interdisciplinary technique and its methods.
Prof. Dr. Shangbang Gao
Dr. Zhitao Hu
Guest Editors
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