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Cells
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Advances in Mitochondrial Calcium Dynamics
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Advances in Mitochondrial Calcium Dynamics

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".

Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 7850

Special Issue Editors

Dr. Laurent Combettes

E-Mail Website
Guest Editor
Faculté des Sciences, Universite Paris-Saclay, CNRS-Inserm, Saint-Aubin, France
Interests: calcium signaling; ER stress; ER–mitochondria interactions
Dr. Geneviève Dupont

E-Mail Website
Guest Editor
Unit of Theoretical Chronobiology, Faculté des Sciences (CP231), Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium
Interests: calcium signaling; computational modeling; calcium oscillations and waves

Special Issue Information

Dear Colleagues,

Mitochondria perform various functions within cells, including ATP production, cell cycle regulation, autophagy, and apoptosis. Because these functions require Ca2+, mitochondria are equipped with Ca2+ transporters and exchangers, which affect cellular Ca2+ signaling. Dysregulation in mitochondrial Ca2+ homeostasis is associated with various pathologies, such as cancer, obesity, or neurodegenerative diseases. 

In recent years, considerable progress has been made in the characterization of mitochondrial Ca2+ dynamics. These studies have highlighted the importance of the reciprocal interactions between the different Ca2+ channels, transporters, and exchangers, which are all affected by mitochondrial voltage and the metabolic status of the organelle. Moreover, mitochondrial Ca2+ changes are exquisitely sensitive to the spatial proximity between other Ca2+-exchanging partners at the level of the endoplasmic reticulum or the plasma membrane. 

This Special Issue invites original research and review articles to help elucidate the mechanisms that regulate mitochondrial Ca2+ dynamics, considering both experimental and modeling investigations. Topics will also include the regulation of mitochondrial functions by Ca2+ in physiological and pathophysiological conditions.

Dr. Laurent Combettes
Dr. Geneviève Dupont
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • calcium signaling
  • mitochondria
  • mitochondrial calcium uniporter (MCU)
  • mitochondria-associated microdomains (MAMs)
  • mitochondrial permeability transition pore (mPTP)

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Published Papers (1 paper)

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Review

17 pages, 1764 KiB  
Review
The Mitochondrial Permeability Transition Pore—Current Knowledge of Its Structure, Function, and Regulation, and Optimized Methods for Evaluating Its Functional State
by René Endlicher, Zdeněk Drahota, Kateřina Štefková, Zuzana Červinková and Otto Kučera
Cells 2023, 12(9), 1273; https://doi.org/10.3390/cells12091273 - 27 Apr 2023
Cited by 37 | Viewed by 7537
Abstract
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-selective membrane pore with a wide range of functions. Although the MPTP has been studied for more than 50 years, its molecular structure remains unclear. Short-term (reversible) opening of the MPTP protects cells [...] Read more.
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-selective membrane pore with a wide range of functions. Although the MPTP has been studied for more than 50 years, its molecular structure remains unclear. Short-term (reversible) opening of the MPTP protects cells from oxidative damage and enables the efflux of Ca2+ ions from the mitochondrial matrix and cell signaling. However, long-term (irreversible) opening induces processes leading to cell death. Ca2+ ions, reactive oxygen species, and changes in mitochondrial membrane potential regulate pore opening. The sensitivity of the pore to Ca2+ ions changes as an organism ages, and MPTP opening plays a key role in the pathogenesis of many diseases. Most studies of the MPTP have focused on elucidating its molecular structure. However, understanding the mechanisms that will inhibit the MPTP may improve the treatment of diseases associated with its opening. To evaluate the functional state of the MPTP and its inhibitors, it is therefore necessary to use appropriate methods that provide reproducible results across laboratories. This review summarizes our current knowledge of the function and regulation of the MPTP. The latter part of the review introduces two optimized methods for evaluating the functional state of the pore under standardized conditions. Full article
(This article belongs to the Special Issue Advances in Mitochondrial Calcium Dynamics)
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