Special Issue "HMGB1 in Health and Disease"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 15 March 2020.

Special Issue Editor

Prof. Atsufumi Kawabata
E-Mail Website
Guest Editor
Laboratory of Pharmacology & Pathophysiology / Faculty of Pharmacy; Kindai University, Higashi-Osaka, 577-8502, Japan
Interests: high mobility group box 1 (HMGB1); T-type calcium channel; hydrogen sulfide; proteinase-activated receptor (PAR); neuroinflamamtion; pain

Special Issue Information

Dear Colleagues,

High mobility group box 1 (HMGB1) functions as a DNA chaperone in the nucleus, and its translocation to the cytoplasm promotes autophagy. HMGB1 is passively released to the extracellular space from dying cells and actively secreted by immune cells, platelets, endothelial cells, etc. in response to infection, inflammatory stimuli, and so on. Extracellular HMGB1 acts as a damage-associated molecular pattern (DAMP) molecule mainly through interaction with pattern-recognition receptors (PRRs), leading to tissue repair or healing, but also aggravation of inflammation or tissue damage. HMGB1 is not only associated with acute inflammatory symptoms, including disseminated intravascular coagulation (DIC), but also with autoimmune disorders, deep venous thrombosis, cancer, etc. Notably, HMGB1 also participates in neuroinflammation, neurodegeneration, and neuronal hyperexcitability and is considered a key molecule in a neuroimmune crosstalk. Thus, HMGB1 is present in the peripheral tissue and CNS plays a wide range of roles in health and disease.

The aim of this Special Issue of Cells is to provide an update of our understandings of the roles played by HMGB1 present in the nucleus, cytoplasm, and extracellular milieu in health and disease. Both original research articles and reviews are welcome.

Prof. Atsufumi Kawabata
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • high mobility group box 1 (HMGB1)
  • alarmin
  • damage-associated molecular patterns (DAMPs)
  • pattern-recognition receptors (PRRs)
  • neuroinflammation
  • neuroimmune crosstalk

Published Papers

This special issue is now open for submission.
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