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Review

Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells

Laboratory of Rare Human Circulating Cells (LCCRH), University Medical Centre of Montpellier, 34295 Montpellier, France
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(8), 1836; https://doi.org/10.3390/cells9081836
Received: 30 June 2020 / Revised: 31 July 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
In the last few decades, the epithelial cell adhesion molecule (EpCAM) has received increased attention as the main membrane marker used in many enrichment technologies to isolate circulating tumor cells (CTCs). Although there has been a great deal of progress in the implementation of EpCAM-based CTC detection technologies in medical settings, several issues continue to limit their clinical utility. The biology of EpCAM and its role are not completely understood but evidence suggests that the expression of this epithelial cell-surface protein is crucial for metastasis-competent CTCs and may not be lost completely during the epithelial-to-mesenchymal transition. In this review, we summarize the most significant advantages and disadvantages of using EpCAM as a marker for CTC enrichment and its potential biological role in the metastatic cascade. View Full-Text
Keywords: circulating tumor cells; epithelial cell adhesion molecule; epithelial cancer; epithelial-to-mesenchymal transition circulating tumor cells; epithelial cell adhesion molecule; epithelial cancer; epithelial-to-mesenchymal transition
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MDPI and ACS Style

Eslami-S, Z.; Cortés-Hernández, L.E.; Alix-Panabières, C. Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells. Cells 2020, 9, 1836. https://doi.org/10.3390/cells9081836

AMA Style

Eslami-S Z, Cortés-Hernández LE, Alix-Panabières C. Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells. Cells. 2020; 9(8):1836. https://doi.org/10.3390/cells9081836

Chicago/Turabian Style

Eslami-S, Zahra, Luis E. Cortés-Hernández, and Catherine Alix-Panabières. 2020. "Epithelial Cell Adhesion Molecule: An Anchor to Isolate Clinically Relevant Circulating Tumor Cells" Cells 9, no. 8: 1836. https://doi.org/10.3390/cells9081836

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