New Insights into Adult Neural Stem Cells and Neurogenesis

Dear Colleagues,

The existence of stem cells or progenitor cells with varying degrees of multipotency and the generation of new neurons persists into adulthood. These neural stem or progenitor cells provide a reserve and the repertoire for adult neurogenesis, which contributes to olfactory system regeneration, learning and memory, and a host of neurophysiological processes. Adult neural stem cell dormancy/activation/proliferation and adult neurogenesis could be modulated by injury, pathological changes in neurodegenerative diseases, as well as physiological aging. Adult neurogenesis occurs to varying degrees in mammals, and has been extensively documented in rodent models. However, to what extent this occurs in non-human primates and humans is only beginning to be revealed, and whether it occurs to any functionally meaningful degree in adult human brains continues to be a contentious issue. Understanding the nature and occurrence of adult neural stem cells and adult neurogenesis would have important implications, particularly with regard to neural regeneration and brain repair. With relevance to the above, recent attempts at in vivo or in situ conversion of non-neuronal cells to neural progenitors or neurons are particularly notable.

The Cells Special Issue on “New insights into adult neural stem cells and neurogenesis” is open to contributions on all aspects of adult neural stem cells and adult neurogenesis. These can take the form of original research papers, full review articles or shorter focused perspectives (2500-3500 words). Relevant topics would include, but are not limited to, the following:

• Adult neural stem/progenitor cells;
• Adult neural stem cell niches;
• Adult neurogenesis in non-human primates;
• Adult neurogenesis in humans;
• Neural stem/progenitor cells in traumatic and ischemic brain injury;
• Neural stem/progenitor cells in neural regeneration;
• In vivo or in situ conversion of non-neuronal cells to neural progenitors or neurons.

Dr. Bor Luen Tang
Guest Editor

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