Identifying Novel Targets and Mechanisms That Drive Pathogenic Fibrosis and Cancer

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 110

Special Issue Editors

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Guest Editor
Department of Pathology, School of Medicine, Stanford University, Stanford, CA, USA
Interests: innate immunity; fibrosis; genetic reprogramming of fibrotic niches
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Stem Cell Research and Regenerative Medicine, Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
Interests: cancer immunology; molecular therapeutics; translational medicine; functional genomics and small molecule inhibitors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fibrosis and cancer are two major health challenges that affect millions of people worldwide. Fibrosis is a pathological process characterized by excessive deposition of extracellular matrix and inflammation, resulting from a dysregulated response to tissue injury. Cancer is a genetic disease driven by mutations that confer abnormal cell survival, proliferation and dissemination. Although fibrosis and cancer have different origins, they share many common features and mechanisms that influence their development and progression. These include the activation of fibroblasts and immune cells, the production of growth factors and cytokines, the induction of epithelial-to-mesenchymal transition, the generation of oxidative stress and cellular senescence, and the modulation of the Hippo pathway. Moreover, fibrosis and cancer are often intertwined, as fibrotic tissue can provide a pro-tumorigenic microenvironment, and cancer cells can induce fibrosis through paracrine signaling. Therefore, understanding the molecular and cellular interactions between fibrosis and cancer may reveal novel therapeutic targets and strategies for both diseases.

This Special Issue aims to provide a comprehensive overview of the current knowledge and recent advances in the field of fibrosis and cancer immunology. We invite original research articles and reviews that cover various aspects of this topic, such as the molecular mechanisms and signaling pathways involved in fibrosis and cancer, the role of immune cells and inflammation in fibrosis and cancer, the crosstalk between fibrosis and cancer in different organs and tissues, the biomarkers and imaging techniques for fibrosis and cancer diagnosis and prognosis, and the potential therapeutic interventions for fibrosis and cancer. We hope that this Special Issue will stimulate further research and foster collaborations among scientists and clinicians working on fibrosis and cancer immunology

Dr. Gerlinde Wernig
Dr. Cristabelle De Souza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • fibrosis
  • cancer
  • extracellular matrix
  • inflammation
  • epithelial-to-mesenchymal transition
  • oxidative stress
  • cellular senescence
  • hippo pathway
  • fibroblast activation

Published Papers

This special issue is now open for submission.
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