Improvement of CART Therapies by Chemical Biology Approaches
A special issue of Biology (ISSN 2079-7737).
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4960
Special Issue Editors
Interests: upstream and downstream bio(pharmaceutical) processing; particularly for cell therapy products
Special Issue Information
Dear Colleagues,
Cell therapies have demonstrated their efficacy in treating or being curative in severe diseases, chronic diseases, and cancers. This Special Issue is devoted to exploring avenues to improve the efficacy of cell therapy products as well as improvements to the manufacturing process, with particular emphasis on CAR products intended for immunotherapy applications. These cells are exposed to a viral vector that integrates the coding sequence for a chimeric antigen receptor (CAR) that allows for binding to target cancer cells. There is significant and problematic patient-to-patient variability in the blood entering the current autologous CART processes, which might be managed better by screening with improved assays potentially identifying relevant biomarkers. Novel use of CRISPR and other gene-editing techniques may potentially give rise to cell lines that are capable of avoiding the body’s host immune response, resulting in allogenic products with more general use and likely lower costs. This issue will cover chemical and biological approaches leading to process and product improvements that include better understanding and/or manipulation of the CAR gene, cellular genetics, and metabolism, as well as non-cellular process inputs such as Lentivirus. Lentivirus construct and manufacturing approaches that produce an improved Lentivirus particle are covered as well.
Prof. Dr. William J. Kelly
Dr. Nooshie Sanaie
Guest Editors
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Keywords
- cell therapy
- immunotherapy
- CART
- T cells
- CD4 or CD8
- Natural Killer (NK) cells
- lentivirus
- autologous
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