Cell-to-Cell Crosstalk as a Target of Therapies

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 4279

Special Issue Editors


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Guest Editor
Department of Molecular Physiology and Neurobiology, University of Wroclaw, ul. Sienkiewicza 21, 50-335 Wroclaw, Poland
Interests: multifunctional proteins; subcellular organization of energy metabolism; cell-to-cell crosstalk
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Molecular Physiology and Neurobiology, University of Wroclaw, Sienkiewicza 21, 50-335 Wroclaw, Poland
Interests: astrocyte-neuron crosstalk; aging; energy metabolism; brain plasticity and memory formation; proteomics; metabolomics; behavioral tests; electrophysiology; enzymology; protein-protein interaction; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In a multicellular organism, no cell is an isolated island. In an organ, tissue and the entire body, cells of different types and origins communicate with each other, sometimes over long distances, creating a healthy physiological environment. This complex set of interactions among cells is referred to as cell-to-cell crosstalk. It occurs through various mechanisms (e.g., paracrine signaling, extracellular vesicles, membrane nanotubes, and "classical" physical contacts between neighboring cells) and mediators (e.g., proteins, microRNA, and metabolites). The aim of this Special Issue is to disseminate and summarize the latest developments in our understanding of cell-to-cell crosstalk and its role in pathogenesis, and how our knowledge of this phenomenon can be used to create new therapies. We welcome original and review articles covering any aspects of this topic.

Dr. Agnieszka Gizak
Dr. Dominika Drulis-Fajdasz
Guest Editors

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Keywords

  • cell-to-cell crosstalk
  • cellular communication
  • microenvironment
  • extracellular vesicles
  • diagnostic tools
  • membrane nanotubes
  • pathogenesis
  • therapy
  • cell metabolism
  • homeostasis

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Published Papers (2 papers)

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Review

115 pages, 3101 KiB  
Review
Cross-Talk Between Cancer and Its Cellular Environment—A Role in Cancer Progression
by Eliza Turlej, Aleksandra Domaradzka, Justyna Radzka, Dominika Drulis-Fajdasz, Julita Kulbacka and Agnieszka Gizak
Cells 2025, 14(6), 403; https://doi.org/10.3390/cells14060403 - 10 Mar 2025
Viewed by 1852
Abstract
The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix and diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells and various immune cells (lymphocytes T and B, NK cells, dendritic cells, monocytes/macrophages, myeloid-derived suppressor cells, and innate lymphoid cells). [...] Read more.
The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix and diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells and various immune cells (lymphocytes T and B, NK cells, dendritic cells, monocytes/macrophages, myeloid-derived suppressor cells, and innate lymphoid cells). A constantly and rapidly growing number of studies highlight the critical role of these cells in shaping cancer survival, metastatic potential and therapy resistance. This review provides a synthesis of current knowledge on the modulating role of the cellular microenvironment in cancer progression and response to treatment. Full article
(This article belongs to the Special Issue Cell-to-Cell Crosstalk as a Target of Therapies)
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42 pages, 1712 KiB  
Review
Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review
by Vicente Javier Clemente-Suárez, Alejandro Rubio-Zarapuz, Pedro Belinchón-deMiguel, Ana Isabel Beltrán-Velasco, Alexandra Martín-Rodríguez and José Francisco Tornero-Aguilera
Cells 2024, 13(23), 1940; https://doi.org/10.3390/cells13231940 - 22 Nov 2024
Cited by 3 | Viewed by 1799
Abstract
Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Objective: The objective of this review is to evaluate the molecular mechanisms by which exercise influences cellular [...] Read more.
Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Multiple Sclerosis. Objective: The objective of this review is to evaluate the molecular mechanisms by which exercise influences cellular metabolism, with a focus on its potential as a therapeutic intervention for neurological disorders. Methods: A comprehensive literature review was conducted using peer-reviewed scientific articles, with a focus on the period between 2015 and 2024, to analyze the effects of exercise on mitochondrial function, oxidative stress, and metabolic health. Results: The findings indicate that exercise promotes mitochondrial biogenesis, enhances oxidative phosphorylation, and reduces reactive oxygen species, contributing to improved energy production and cellular resilience. These metabolic adaptations are associated with delayed disease progression and reduced symptoms in patients with neurodegenerative conditions. Additionally, integrating exercise with nutritional strategies may further enhance therapeutic outcomes by addressing metabolic disturbances comprehensively. Conclusions: This review concludes that personalized exercise protocols should be developed to optimize metabolic benefits for patients with neurological diseases, while future research should focus on biomarker development for individualized treatment approaches. These findings highlight the importance of non-pharmacological interventions in managing neurodegenerative diseases. Full article
(This article belongs to the Special Issue Cell-to-Cell Crosstalk as a Target of Therapies)
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