Endoplasmic Reticulum Stress and Human Disease: Lessons from Animal Models
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (15 June 2025) | Viewed by 2263
Editor
Interests: ER stress; cell death; drosophila; UPR; stress response
Special Issue Information
Dear Colleagues,
The endoplasmic reticulum (ER) is a central hub for protein synthesis and processing. It is key to lipid synthesis and indispensable for maintaining calcium homeostasis. Disruptions in ER function can precipitate ER stress, a cellular response that has been linked to a diverse spectrum of human diseases, encompassing neurodegenerative disorders, diabetes, cardiovascular conditions, and various cancers. Interestingly, ER stress has also been associated with physiological processes.
This Special Issue of Cells is dedicated to uncovering the complex interplay between ER stress and disease pathology. A focal point of this Issue is related research on animal models, which offer a controlled experimental framework to elucidate the physiological impacts of ER stress. These models are crucial for dissecting the pathomechanisms of diseases driven by ER stress, providing a deeper understanding of the molecular and cellular dynamics at play.
This Issue will delve into the cellular and molecular intricacies of ER stress, its contribution to the etiology of certain diseases, and the prospects for developing targeted therapeutic strategies. We encourage submissions of both original research and comprehensive reviews that contribute to our collective understanding of ER stress and its implications for human health.
We warmly invite researchers to submit their work to this Special Issue, and we eagerly anticipate collaborating with the scientific community to disseminate these vital findings through their publication in Cells.
Dr. Sébastien Gaumer
Guest Editor
Manuscript Submission Information
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Keywords
- endoplasmic reticulum (ER)
- ER stress
- human diseases
- neurodegenerative disorders
- diabetes
- cardiovascular diseases
- cancer
- animal models
- pathomechanisms
- therapeutic strategies
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