Metabolic Disorders: Insights into Pathogenesis and Novel Therapeutic Strategies

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: 30 November 2025 | Viewed by 3459

Special Issue Editors


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Guest Editor
Department of Cardiology, Preventive Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Street, 15127 Melissia, Greece
Interests: cardiometabolic medicine; cardiovascular endocrinology and metabolism; preventive cardiology and rehabilitation; heart failure; cardiogeriatrics; clinical epidemiology
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Guest Editor Assistant
1. Department of Cardiology, Preventive Cardiology & Heart Failure Outpatient Clinic, Sismanogleio-Amalia Fleming General Hospital, 14 25is Martiou Street, 15127 Melissia, Greece
2. School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias, 11527 Athens, Greece
3. NT-CardioMetabolics, Clinic for Metabolism and Athletic Performance, 47 Tirteou Street, 17564 Palaio Faliro, Greece
Interests: cardiometabolic medicine; cardiovascular endocrinology and metabolism; preventive cardiology and rehabilitation; heart failure; cardiogeriatrics; clinical epidemiology

Special Issue Information

Dear Colleagues,

This Special Issue, “Metabolic Disorders: Insights into Pathogenesis and Novel Therapeutic Strategies”, focuses on the complex interplay of genetic, environmental, and lifestyle factors driving metabolic diseases such as diabetes, obesity, metabolic syndrome, and rare hereditary conditions. This issue aims to explore advances in understanding the molecular mechanisms underlying these disorders, their connections with comorbidities like cardiovascular and neurodegenerative diseases, and innovative therapeutic approaches, including pharmacological, dietary, and precision medicine strategies. Key areas of interest include the role of inflammation, gut microbiota, metabolomics, and other omics technologies in pathogenesis and diagnosis. This issue will also address public health strategies, the integration of digital health tools, and the socioeconomic impacts of metabolic disorders. We welcome submissions of original research, comprehensive reviews, and case reports that advance the understanding of metabolic diseases or propose novel interventions. Communications and short notes presenting new concepts, pilot studies, or preliminary findings are also encouraged. This Special Issue aims to foster a multidisciplinary dialogue to drive progress in managing and preventing metabolic disorders effectively.

Dr. Maria Nikolaou
Guest Editor

Dr. Nikolaos Theodorakis
Guest Editor Assistant

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Keywords

  • metabolic disorders
  • cardio-renal–hepatic–metabolic syndrome
  • cardiometabolic medicine
  • obesity
  • diabetes mellitus

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Published Papers (2 papers)

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2 pages, 147 KiB  
Correction
Correction: Theodorakis, N.; Nikolaou, M. The Human Energy Balance: Uncovering the Hidden Variables of Obesity. Diseases 2025, 13, 55
by Nikolaos Theodorakis and Maria Nikolaou
Diseases 2025, 13(4), 108; https://doi.org/10.3390/diseases13040108 - 3 Apr 2025
Viewed by 171
Abstract
There was an error in the original publication [...] Full article
19 pages, 1049 KiB  
Perspective
The Human Energy Balance: Uncovering the Hidden Variables of Obesity
by Nikolaos Theodorakis and Maria Nikolaou
Diseases 2025, 13(2), 55; https://doi.org/10.3390/diseases13020055 - 13 Feb 2025
Cited by 2 | Viewed by 2945 | Correction
Abstract
Obesity has emerged as a global epidemic, creating an increased burden of weight-related diseases and straining healthcare systems worldwide. While the fundamental principle of energy balance—caloric intake versus expenditure—remains central to weight regulation, real-world outcomes often deviate from simplistic predictions due to a [...] Read more.
Obesity has emerged as a global epidemic, creating an increased burden of weight-related diseases and straining healthcare systems worldwide. While the fundamental principle of energy balance—caloric intake versus expenditure—remains central to weight regulation, real-world outcomes often deviate from simplistic predictions due to a multitude of physiological and environmental factors. Genetic predispositions, variations in basal metabolic rates, adaptive thermogenesis, physical activity, and nutrient losses via fecal and urinary excretion contribute to interindividual differences in energy homeostasis. Additionally, factors such as meal timing, macronutrient composition, gut microbiota dynamics, and diet-induced thermogenesis (DIT) further modulate energy utilization and metabolic efficiency. This Perspective explores key physiological determinants of the energy balance, while also highlighting the clinical significance of thrifty versus spendthrifty metabolic phenotypes. Key strategies for individualized weight management include precision calorimetry, circadian-aligned meal timing, the use of protein- and whole food diets to enhance DIT, and increases in non-exercise activity, as well as mild cold exposure and the use of thermogenic agents (e.g., capsaicin-like compounds) to stimulate brown adipose tissue activity. A comprehensive, personalized approach to obesity management that moves beyond restrictive caloric models is essential to achieving sustainable weight control and improving long-term metabolic health. Integrating these multifactorial insights into clinical practice will enhance obesity treatment strategies, fostering more effective and enduring interventions. Full article
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