Special Issue "State of the Art and Future Trends in Nanostructured Biocatalysis"
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 46237
Interests: nanomaterials with catalytic properties; nanotechnology for bio-applications; biosensing technology for rapid and sensitive detection; intelligent and 3D-printed devices integration
Interests: biocatalysis; enzymatic analysis; Environmental biotechnology
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According to a definition provided by the Royal Society, as a key technology of the 21st century, nanotechnology refers to the design, characterization, production, and application of structures, devices, and systems by controlling shape and size at the nanometer scale. Applied to biocatalysis, a subarea of enzyme biotechnology, nanobiocatalysis has rapidly developed in the recent past. It combines advances in nanotechnology such as the generation of various nanoscale materials and their physicochemical/optical properties with the excellent characteristics of biocatalysts into an innovative technology.
An important application field is the immobilization of enzymes onto the surface of nanostructured supports (e.g., organic/inorganic (magnetic) NPs, carbon-based nanotubes, mesoporous materials, nanofiber membranes, virus-like particles, etc.) for the sustainable production of goods and chemicals, including biodiesel. In contrast to bulk solid materials, these carriers are characterized by a high surface, resulting in a significantly reduced mass transfer limitation and comparatively high enzyme loading. In addition, they often contribute to a stabilization of the fragile molecules by providing a biocompatible surrounding using immobilization strategies such as “grafting onto” and “grafting from” and other strategies (e.g., the formation of single-enzyme nanoparticles).
Quantum dot (QD)-based photoelectrochemical sensors for analyte detection and the analysis of biospecific interactions, and FRET reporter molecules employed, for example, for the identification of enzyme functions make use of the unique electronic and surface-related properties of these colloidal semiconductive nanoparticles. Enzymatic bioelectrocatalysis with electron transfer between an enzyme and a nano-porous electrode is the principle of many biosensor devices used for analytical purposes, as well as enzymatic biofuel cells that convert chemical energy into electrical power.
Nanobiocatalysis also has an impact in the medical area, in connection with the administration and controlled release of drugs, and finds application in proteomic analysis. Biocomputing nanoplatforms serve as therapeutics and diagnostics. Finally, it is possible to synthesize inorganic nanoparticles that mimic natural enzymes. These artificial enzymes are superior to their natural counterparts in terms of stability and cost efficiency.
Dr. Nan Cheng
Prof. Dr. Peter Grunwald
Manuscript Submission Information
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- nanostructured materials
- carbon-based nanoparticles
- quantum dots
- single enzyme nanoparticles
- therapeutic applications