Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes

Dear Colleagues,

Brain and central nervous system (CNS) tumors remain among the most complex and heterogeneous malignancies, requiring a highly integrated multidisciplinary approach to optimize diagnosis, treatment, and long-term outcomes. In recent years, the convergence of precision neurosurgery, advanced neuroimaging, intraoperative mapping, and molecular profiling has reshaped the way clinicians understand and manage these diseases.

This Special Issue aims to explore the evolving role of surgery within the multidisciplinary management of CNS tumors—from gliomas and meningiomas to metastatic and pediatric entities—and its interplay with radiotherapy, systemic therapies, and molecularly guided precision medicine. Emphasis will be placed on the integration of neurosurgical, neuro-oncological, radiotherapeutic, and neuropathological expertise to improve patient outcomes.

Contributions are invited on translational research, innovative surgical and imaging techniques, intraoperative monitoring, liquid biopsy, and molecular predictors of surgical outcomes, as well as studies highlighting the synergy between surgery and adjuvant or neoadjuvant treatments. Topics may also include the use of artificial intelligence, radiomics, and digital pathology to support decision-making in a multidisciplinary setting and to personalize therapeutic strategies.

Both clinical and translational studies, systematic reviews, and illustrative case series that provide novel insights into the optimization of surgical management and its impact on patient outcomes are welcome.

We believe this scope will allow for a comprehensive and contemporary view of CNS tumor management, fully aligned with Cancers’ multidisciplinary mission.

Dr. Paolo Tini
Dr. Salvatore Chibbaro
Dr. Mario Ganau
Guest Editors

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