Oxidative Stress and Cancer

Dear Colleagues,

Over 7,500 articles on oxidative stress related cancers are substantial evidence of the paramount importance of the control of cellular redox homeostasis which is challenged, throughout life, by sustained oxidative stress, chronic inflammation, and excessive antigen-loading. Oxidative stress-induced activation of NADPH oxidase and peroxisome proliferators-activated receptors, oxidants and inflammatory mediators, i.e. IL-6, IL-10, TNF-α, PGs, alterations of redox state of binding proteins, DNA mutations and induction of early response genes and hematopoietic activation seem to be common elements in the induction of hyperplasia, neoplasia, cancer metastasis, and angiogenesis. Therefore, potential health benefits of a number of antioxidants or anti-inflammatory agents, and maintenance of cellular oxido-redox status are crucial for optimal tissue function. This is a complicated topic which can be investigated from a number of perspectives. Our final goal is the compilation of a special issue providing an integrated understanding / identification of developmental phases of oxidative stress-induced cancers that will assist professionals towards effective progress on cancer war.

Thank you for your collaboration.

Prof. Dr. Alba Minelli
Guest Editor