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Open AccessReview

Role of Uncoupling Proteins in Cancer

Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears/Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Illes Balears, Spain
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Cancers 2010, 2(2), 567-591; https://doi.org/10.3390/cancers2020567
Received: 4 March 2010 / Revised: 31 March 2010 / Accepted: 12 April 2010 / Published: 16 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance. View Full-Text
Keywords: uncoupling proteins; cancer; proton leak; mitochondria; chemoresistance; carcinogenesis; oxidative stress uncoupling proteins; cancer; proton leak; mitochondria; chemoresistance; carcinogenesis; oxidative stress
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Valle, A.; Oliver, J.; Roca, P. Role of Uncoupling Proteins in Cancer. Cancers 2010, 2, 567-591.

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