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The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics
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Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del giochetto, 06124 Perugia, Italy
Author to whom correspondence should be addressed.
Cancers 2010, 2(2), 483-497;
Received: 26 February 2010 / Revised: 18 March 2010 / Accepted: 12 April 2010 / Published: 13 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors. NF-E2-related factor 2 (Nrf2) encodes for antioxidant and general cytoprotection genes, while NF-κB regulates the expression of pro-inflammatory genes. A variety of anti-inflammatory or anti-carcinogenic phyto-chemicals suppress NF-κB signalling and activate the Nrf2-ARE pathway. In this review we consider the role of Nrf2 and NF-κB in cancer pathogenesis and progression, focusing on their concerted modulation and potential cross-talk. View Full-Text
Keywords: oxidative stress; chemoprevention; chemotherapy oxidative stress; chemoprevention; chemotherapy
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MDPI and ACS Style

Bellezza, I.; Mierla, A.L.; Minelli, A. Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression. Cancers 2010, 2, 483-497.

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