Calcium-Linked Messaging in Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 30 June 2026
Special Issue Editor
Interests: TRP; cancer biology; apoptosis; autophagy; senescence; circulating stem cell; chemoresistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is well established that cancer cells exhibit modified calcium signaling that facilitates several pro-tumoral processes, including proliferation, angiogenesis, exosome release, invasion, loss of death pathways, and response to chemotherapy. Consequently, the impairment of Ca2+ homeostasis is considered a crucial driver of cancer initiation and progression. Accumulating evidence indicates that the alterations of intracellular Ca2+ flux arise from aberrant expression or function of cation channels, pumps, sensors, and transporters, which, therefore, represent attractive targets for the development of innovative anticancer drugs.
Recently, interorganellar Ca2+ communication has gained considerable attention. These calcium exchanges between organelles are altered in cancer and promote tumor progression by influencing cell metabolism and cell fate.
This Special Issue aims to gather current knowledge on on the role of Ca2+ signaling in cancer, with a focus on the following:
- Membrane contact sites between mitochondria and endoplasmic reticulum or lysosomes;
- Interorganelle platforms connecting endosomes and the plasma membrane;
- Interorganelle Ca2+ flux and its impact on cancer cell metabolism and fate;
- Alterations of membrane contact sites to promote migration and invasion;
- Mitoflash and tumor progression;
- Ca2+ interplay between organelles and the exosome release.
Dr. Amantini Consuelo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- interorganellar Ca2+ communication
- membrane contact sites
- tumor progression
- intracellular Ca2+ flux
- cation channels
- calcium dysregulation
- cell fate
- targeted therapy
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