Special Issue "Hepatocellular Cancer Treatment"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 15 July 2019

Special Issue Editor

Guest Editor
Prof. Dr. Renuka Iyer

Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA
Website | E-Mail
Interests: hepatocellular cancer, wooddhuck model of liver cancer, neuroendocrine cancer, biliary cancer, novel therapeutics

Special Issue Information

Dear Colleagues,

Progress in hepatocellular cancer has been remarkable in the last year after a decade of unsuccessful trials. Besides great strides in treating hepatitis C, we now have a number of molecularlytargeted drugs and immunotherapies, and the best treatment option and sequence for advanced patients is evolving. Early detection, optimal selection of candidates for surgery, and liver-directed therapies remain challenging. This Special Issue will discuss important basic science developments in our understanding of liver cancer biology; innovations in the treatment of localized disease; and novel therapeutics, especially immunotherapy agents and upcoming trials that may impact the treatment of hepatocellular cancer in the years to come.

Prof. Dr. Renuka Iyer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Cancers 2019, 11(4), 509; https://doi.org/10.3390/cancers11040509
Received: 28 February 2019 / Revised: 29 March 2019 / Accepted: 8 April 2019 / Published: 10 April 2019
PDF Full-text (412 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The neutrophil-to-lymphocyte ratio (NLR) has recently been reported to predict the prognosis of hepatocellular carcinoma (HCC). We explored whether NLR predicted the survival of patients with HCC undergoing transarterial chemoembolization (TACE), and developed a predictive model. In total, 1697 patients with HCC undergoing [...] Read more.
The neutrophil-to-lymphocyte ratio (NLR) has recently been reported to predict the prognosis of hepatocellular carcinoma (HCC). We explored whether NLR predicted the survival of patients with HCC undergoing transarterial chemoembolization (TACE), and developed a predictive model. In total, 1697 patients with HCC undergoing TACE as first-line therapy at two university hospitals were enrolled (derivation set n = 921, internal validation set n = 395, external validation set n = 381). The tumor size, tumor number, AFP level, vascular invasion, Child–Pugh score, objective response after TACE, and NLR, selected as predictors of overall survival (OS) via multivariate Cox’s regression model, were incorporated into a 14-point risk prediction model (SNAVCORN score). The time-dependent areas under the receiver-operating characteristic curves for OS at 1, 3, and 5 years predicted by the SNAVCORN score were 0.812, 0.734, and 0.700 in the derivation set. Patients were stratified into three risk groups by SNAVCORN score (low, 0–4; intermediate, 5–9; high, 10–14). Compared with the low-risk group, the intermediate-risk (HR 3.10, p < 0.001) and high-risk (HR 7.37, p < 0.001) groups exhibited significantly greater mortality. The prognostic performance of the SNAVCORN score including NLR in patients with HCC treated with TACE was remarkable, much better than those of the conventional scores. The SNAVCORN score will guide future HCC treatment decisions. Full article
(This article belongs to the Special Issue Hepatocellular Cancer Treatment)
Figures

Figure 1

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top