Insight into Fatty Acid Metabolism in Colorectal Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 13193
Special Issue Editor
Interests: colorectal cancer; metastasis; lipid metabolism; fatty acid synthase (FASN) and de novo lipid synthesis; FASN-targeted therapies and CRC resistance; exogeneous fatty acid uptake; colorectal cancer and obesity
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Despite advances in our understanding of the molecular basis of CRC and the increasing number of targeted therapies, treatment of CRC frequently remains disappointing.
Altered lipid metabolism, a common feature of cancer cells, is rapidly emerging as a potential target for therapeutic intervention in CRC. Fatty acids, which can be obtained from diet or synthesized de novo from carbohydrate precursors, are important substrates for energy metabolism and essential components of cell membranes. Lipids are also implicated in signal transduction; intracellular trafficking; posttranslational modifications; and cell secretion, migration, and invasion.
Activation of lipogenesis and overexpression of lipogenic enzymes such as fatty acid synthase (FASN) correlate with a poorer prognosis and shorter disease-free survival in CRC. While most tumors are dependent on fatty acid synthesis, they can also scavenge lipids from their environment. Epidemiological studies demonstrate that a high-fat diet and obesity increase the risk of CRC 1.5–2.0-fold. Furthermore, recent data show that rates of CRC are increasing in younger populations and obesity is being one of the major factors that contribute to the raising rate of this disease. These new alarming data support the urgent need to better understand the mechanisms behind how lipid metabolism contributes to the initiation and progression of CRC.
Lipid metabolism has been actively explored as a therapeutic target, and several clinical trials are underway. Even though early data from clinical trials show promising results, there are multiple unanswered questions about lipid-driven metabolic alterations that promote CRC and about how diet and obesity contribute to lipid-metabolism-targeted therapy responses. The Special Issue “Insight into Fatty Acid Metabolism in Colorectal Cancer” will bring together experts in the field of lipid metabolism in CRC to share novel research, expand our knowledge, and stimulate discussions on this topic.
Dr. Yekaterina Zaytseva
Guest Editor
Manuscript Submission Information
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Keywords
- colorectal cancer
- colorectal cancer metastasis
- de novo lipid synthesis
- fatty acid transporters and fatty acid uptake in CRC
- obesity and CRC
- lipid metabolism-targeted therapies
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