Special Issue "Exosomes in Cancer Development"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 June 2013)
Prof. Dr. Pamela Russell
Australian Prostate Cancer Research Centre - Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4102, Austrialia
Phone: +61 7 3443 7240
Fax: +61 7 3176 7440
Interests: advanced prostate cancer; plasma derived exosomes; urine derived exosomes, exosomes from animal models of cancer
Dr. Aled Clayton
Institute of Cancer & Genetics, School of Medicine, Cardiff University, Velindre Cancer Centre, Cardiff, CF14 2TL, UK
Interests: cancer exosomes; tumour stroma; immune evasion; prostate cancer; mesothelioma
This issue invites investigators to contribute original research reports as well as review articles that describe studies on cancer exosomes.
Recent studies have shown that most cells constitutively secrete nanovesicles (50-150 nm) called exosomes through a distinct biogenesis pathway, not via the Golgi secretory pathway. The exosomal contents reflect the cells of origin. The release of exosomes is exacerbated in tumors leading to their increased presence in plasma, ascites, urine and other bodily fluids of cancer patients. However, the exosome field is still nascent, and lacks tools required for selective isolation of cancer-derived exosomes separate from other exosomes produced by other cells that are found in bodily fluids.
Recent advances in genomic, transcriptomic, proteomic, and metabolomic research pave the way to a more comprehensive understanding of the complex changes taking place in the locally involved cells and tissues, and of the interplay between the tumor and the rest of the organism. Exosomes have a double layered membrane containing an array of proteins, microRNA or mRNA, lipids, metabolites and potentially other tumor markers. Moreover, the exosomes are known to be involved in cell to cell interactions, including those which “educate” the tumor niche, encouraging the growth of tumor cells in secondary environments.
Potential topics include, but are not limited to:
- Development of new techniques/assays for isolation of cancer-specific exosomes from bodily fluids and validation of these techniques against existing methodology.
- Identification of novel prognostic biomarkers isolated from cancer derived exosomes in the urine or circulation of cancer patients, eg that can predict metastases, or indicate treatment response and treatment resistance
- Identification of cell to cell interactions between exosomes from cancer cells and other tissues and their role in cancer initiation or progression. These can include preclinical studies.
- Studies that shed light on the mechanisms of release of exosomes from cancer cells.
- Discussion of possible future developments based on studies of cancer specific exosomes towards a better understanding of cancer biology, and how such advances may be translated into improved patient management.
Prof. Dr. Pamela Russell
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
- cancer-specific exosome capture
- exosomal biomarkers
- exosomal miRNA
- exosomal proteomics
- exosomal metabolomics
- exosomal lipidomics
- cell to cell communications