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Cancers
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Basal Cell Carcinoma of the Head and Neck
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Basal Cell Carcinoma of the Head and Neck

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 8064

Special Issue Editor

Dr. Guido Valente

E-Mail Website
Guest Editor
Dipartimento di Medicina Traslazionale, Università del Piemonte Orientale, 6-13100 Vercelli, Italy
Interests: head and neck tumors; immunohistochemistry; molecular pathology; tumor microenvironment

Special Issue Information

Dear Colleagues,

Basocellular carcinoma (basalioma) is the most frequent human neoplasia, accounting for 15% of all tumors. Since sun exposition is one of the classical risk factors, more than 50% of basaliomas are found in the head and neck; another quite typical site is the trunk (about 20%), whereas other regions are more rarely involved. The simple surgical excision is the elected therapy in most of the cases, however tumors involving extensive areas of the face, or showing multiple recurrences, should be treated by complex surgical procedures (for instance, Mohs surgery). In case of metastases or multiple recurrences, chemotherapy using Vismodegib, targeting Hedgehog signaling pathway, may be also scheduled.

A Special Issue of Cancers, entitled “Basal Cell Carcinoma of the Head and Neck” is now in preparation by a group of expert dermatopathologists, clinical dermatologists, and dermosurgeons. It will include the following contents:

- An update on biological, diagnostic and therapeutic tools in basaliomas
- A survey of pitfalls in diagnostic histopathology
- Cutaneous lesions simulating basaliomas
- The main problems of surgical treatments, with particular reference to Mohs surgery
- A study on the changes in cutaneous microenvironment induced by medical therapy with Vismodegib
- A series of head and neck basaliomas associated to genetic skin diseases

Dr. Guido Valente
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • basocellular carcinoma
  • basal cell carcinoma
  • basaliomas
  • head and neck cancers
  • election therapy
  • cutaneous lesions
  • surgical treatments
  • Mohs surgery
  • genetic skin diseases

Published Papers (2 papers)

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Research

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13 pages, 297 KiB  
Article
Multiple Basal Cell Carcinomas in Immunocompetent Patients
by Paola Savoia, Federica Veronese, Lara Camillo, Vanessa Tarantino, Ottavio Cremona and Elisa Zavattaro
Cancers 2022, 14(13), 3211; https://doi.org/10.3390/cancers14133211 - 30 Jun 2022
Cited by 1 | Viewed by 1427
Abstract
Background: The onset of multiple BCCs is a relatively common condition, not only among patients undergoing chronic treatment with immunosuppressant drugs, but also in the general population, although specific risk factors for immunocompetent patients have not been identified. A putative role of somatic [...] Read more.
Background: The onset of multiple BCCs is a relatively common condition, not only among patients undergoing chronic treatment with immunosuppressant drugs, but also in the general population, although specific risk factors for immunocompetent patients have not been identified. A putative role of somatic mutations in the hedgehog pathway should be considered. Methods: This study is a retrospective observation of all patients diagnosed and surgically treated for BCCs during 5 years at our Dermatological Division. For these patients, we evaluated clinical and histopathological characteristics and data about possible risk factors for BCC. Results: Five-hundred and six patients affected by multiple BCCs, accounting for the 24.2% of the entire sample, have been identified. In these patients, the total number of BCCs was 1516, ranging from 2 to 11. Subjects affected by multiple BCCs were more frequently males, with an older age at diagnosis; multiple BCCs developed mainly on the trunk and were often represented by a nodular histotype. The multivariate analysis highlighted that male gender, older age, nodular BCC, or face involvement at the first diagnosis are risk factors for the development of multiple BCCs. Conclusions: The frequency of multiple BCCs even among the non-immunocompromised population underlines the need to subject patients to a close surveillance program, to allow early diagnosis and treatment of additional cancers. Full article
(This article belongs to the Special Issue Basal Cell Carcinoma of the Head and Neck)

Review

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14 pages, 2476 KiB  
Review
Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles
by Izabela Łasińska, Aleksandra Zielińska, Jacek Mackiewicz and Eliana B. Souto
Cancers 2022, 14(11), 2778; https://doi.org/10.3390/cancers14112778 - 03 Jun 2022
Cited by 5 | Viewed by 5870
Abstract
Skin cancer is the most common type of carcinoma diagnosed worldwide, with significant morbidity and mortality rates among Caucasians, in particular basal cell carcinoma (BCC). The main risk factors of BCC are well-identified, and there are many chemotherapeutic drugs available for its treatment. [...] Read more.
Skin cancer is the most common type of carcinoma diagnosed worldwide, with significant morbidity and mortality rates among Caucasians, in particular basal cell carcinoma (BCC). The main risk factors of BCC are well-identified, and there are many chemotherapeutic drugs available for its treatment. The effectiveness of therapeutic options is governed by several factors, including the location of the tumor, its size, and the presence of metastases (although rare for BCC). However, available treatments are based on non-targeted approaches, which encounter a significant risk of systemic toxicity in several organs. Site-specific chemotherapy for BCC has been proposed via the loading of anticancer drugs into nanoparticles. Among various types of nanoparticles, in this review, we focus on potential new regimens for the treatment of BCC using classical anticancer drugs loaded into novel lipid nanoparticles. To meet patient aesthetic expectations and enhance the effectiveness of basal cell carcinoma treatment, new therapeutic topical strategies are discussed, despite a limited number of reports available in the literature. Full article
(This article belongs to the Special Issue Basal Cell Carcinoma of the Head and Neck)
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