Advanced Research in Multiple Myeloma, Volume II
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 2265
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue is the second edition of the Special Issue "Advanced Research in Multiple Myeloma" (https://www.mdpi.com/journal/cancers/special_issues/research_multiple_myeloma).
Multiple myeloma (MM) is the second most common hematological malignancy, with an incidence of 4.5–6 per 100,000 per year and a median age at diagnosis of 70 years. Although the use of high-dose therapy, autologous stem cell transplantation, and several new drugs (e.g., proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies) has led to significantly improved survival for MM patients, the majority will experience several relapses and will eventually die from the disease.
Trying to modify this evolution and aiming to cure the disease by understanding its pathogenesis, research in MM is currently focused on several aspects: 1) the role of genomic/epigenomic data and of specific modifications in the bone marrow microenvironment in the development of MM from its initial conditions (MGUS and smoldering MM) and in its ulterior clinical evolution; 2) the use of standard minimal residual disease (MRD) assessment (through next-generation sequencing, next-generation flow, and PET-CT) to assess treatment response and/or to guide the therapeutic schema in an attempt to optimize patient outcome (not only at diagnosis, but also in subsequent lines of therapy); 3) the use of alternative sources to assess MRD such as peripheral blood, and of alternative methods, including mass spectrometry, immune-based imaging, and DW-MRI; and 4) the clinical benefit, mechanisms of action, and resistance and determinants of response of the most advanced immune-based treatments applied at different time-points of the disease, including CAR-T cells and monoclonal antibodies.
To compile information regarding the most advanced myeloma research, we have planned this Special Issue of Cancers, to which we invite you to participate.
Dr. Noemí Puig
Guest Editor
Manuscript Submission Information
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Keywords
- multiple myeloma
- genomic/epigenomic
- minimal residual disease (MRD)
- alternative sources /methods
- immune-based treatments
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