Pathogenesis, Prognosis, Prediction and Personalized Therapy in Breast Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 5491
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, traditional prognostic factors in breast cancer such as tumor size and nodal involvement in EBC and disease localization in MBC have lost a lot of their relevance in decision making. Prognostic factors such as HER2neu overexpression, proliferation measured by Ki67 statically and dynamically, and mutation sets in cfDNA, as well as predictive markers such as the aforementioned and PD-L1, PIK3CA mutation status, ESR1 mutation status, and many more have gained importance. This development has just begun to unfold, and diagnostic tools such as next-generation sequencing and investigation of the tumor microenvironment are the next step in this direction of personalized approaches. As we learn more about the biology of breast cancer, this also affects our view of how breast cancer is developing and why, initially, local breast cancer becomes a systemic disease. This Special Issue covers the spectrum from pathogenesis and the development of metastases over prognosis to prediction in early and metastatic breast cancer and includes manuscripts from pathologists, biologists, and breast oncologists.
Prof. Dr. Hans-Christian Kolberg
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- pathogenesis
- prognostic factors
- predictive factors
- liquid biopsy
- multigene assay
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