Molecular Insights into Cancer Metabolism, Metastasis, and Immune Evasion
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 3281
Special Issue Editor
Interests: metastasis; molecular pathway; cancer models; metabolism; tumor microenvironment; drug screening and development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metastatic disease is responsible for approximately 90% of cancer deaths. In order for metastasis to be successful, cancer cells must evade detection and destruction by the immune system. This evasion is facilitated by factors secreted by the primary tumor that shape both the intratumoral microenvironment and the systemic immune landscape. While some components of the immune system contribute to antitumor immunity, others are involved in tumor progression. There is increasing evidence that tumors continuously interact with the immune system by altering their metabolic pathways to adapt to different microenvironments and therapeutic interventions. Therefore, targeting cancer metabolic heterogeneity represents an innovative therapeutic strategy with the potential to prevent metastasis and the immune escape of cancer cells.
This Special Issue aims to advance our understanding of the mechanistic basis of cancer metabolism, metastasis, and immune evasion. We seek to bridge three major topics—cancer metabolism, metastasis, and immune evasion—with a particular focus on molecular determinants and regulations. Our goal is to formulate novel mechanism-driven counter-strategies and therapeutic combinations to facilitate clinical translation. Original research articles and comprehensive reviews are welcome for submission to this Special Issue. Articles are expected to cover, but are not limited to, the following topics:
- Tumor–immune cell crosstalk in metastasis formation.
- Mechanistic insights into how primary tumors hijack tumor–immune interactions to enhance their metastatic potential.
- The molecular mechanisms involved in the intricate interactions within cancer metabolism.
- The metabolic patterns and heterogeneity in tumor developmental stages, ranging from initiation to metastasis.
- Potential approaches to manipulating the tumor–immune interactome for therapeutic benefits.
Dr. Yong Teng
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- cancer metabolism
- metastasis
- immune evasion
- tumor–immune interactions
- combination therapy
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