Tumor, Tumor-Associated Macrophages, and Therapy
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 27951
Special Issue Editors
Interests: immuno-oncology; tumor immunotherapy; tumor stem cells; tumor immunosuppression; targeted therapy; drug resistance; metastasis; cell of origin of cancer; metabolomics and cancer; microbial dysbiosis and cancer
Special Issue Information
Dear Colleagues,
Macrophages are innate immunocytes and have exceptionally diverse functions that include killing pathogens, tissue homeostasis, and wound healing. Macrophages are extremely plastic cells, and they are two polarization states: classically activated M1 phenotype (pro-inflammatory and antitumor) and alternatively activated M2 (anti-inflammatory and protumorigenic); however, dependent on signaling in the tumor microenvironment (TME), they interchange phenotypes. Tumor-associated macrophages (TAMs) are macrophages that are recruited or infiltrated into the TME, and they are highly immunosuppressive and play major roles in inhibiting active T-cell immune surveillance of tumors, tumor initiation, growth, development, and metastasis by secreting a wide variety of cytokines, growth factors, inflammatory substrates, and proteolytic enzymes. Recent studies have strongly suggested that TAMs can be a potential target in cancers to enhance the host antitumor mechanisms. This Special Issue will highlight the diverse roles of macrophages in cancer, covering high-impact basic and clinical studies on macrophage polarization, macrophage-based immunotherapy in tumors, with an emphasis on macrophage targets, tumor stem cells and macrophages, small molecules targeting macrophages, and immune signaling axes that offer novel ideas and strategies to develop and improve approaches targeting these cells in tumors
Dr. Parthasarathy Chandrakesan
Dr. Janani Panneerselvam
Guest Editors
Manuscript Submission Information
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Keywords
- tumor-associated macrophages
- macrophage polarization
- tumor stem cells
- tumor microenvironment
- immunosuppression
- host immunity
- innate immunity
- adaptive immunity
- immune escape
- immunotherapy
- immunotherapy resistance
- cytokines/chemokines
- T-cell activity
- immune checkpoint inhibitors
- translational and clinical research
- immuno-modulation and cancer
- immune infiltration
- tumor metastasis
- antitumor immunity
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