Immunotherapy in Melanoma: Recent Advances and Future Directions (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1504

Special Issue Editors


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Guest Editor
First Department of Medicine, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
Interests: melanoma; immunotherapy; targeted therapy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
First Department of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Interests: melanoma; immunotherapy; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of a previous Special Issue entitled “Immunotherapy in Melanoma: Recent Advances and Future Directions” (https://www.mdpi.com/journal/cancers/special_issues/IM).

Looking beyond the pandemic, immune-checkpoint inhibitors (ICIs) continue to offer long-term remission in melanoma, either in an adjuvant or a metastatic setting. At the same time, the development of new immunotherapeutic agents (e.g., relatlimab and bempegaldesleukin) or combinatorial regimens (e.g., immune/targeted combinations, intralesional infusions and ICIs) and the identification of intratumoral or circulating biomarkers continue to open new horizons and produce new questions for immune-mediated treatments. Issues such as the duration and the exact dose of anti-PD1/anti-PDL1 and anti-CTLA4 agents in metastatic and locoregional disease, the stage of early melanoma that should be treated with ICIs and the potential of intralesional infusions are still under consideration and an open field for debate. To this end, this Special Issue of Cancers aims to explore the constantly remodeled area of immunotherapy in melanoma management in the post-COVID-19 era and tries to recap where we are and where we are going in terms of the knowledge on immune-mediated therapies in melanoma.

We look forward to receiving your contributions.

Dr. Dimitrios C. Ziogas
Prof. Dr. Helen Gogas
Guest Editors

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Keywords

  • melanoma
  • immunotherapy
  • prognostic and predictive biomarkers
  • recurrence-free and overall survival
  • adjuvant/neoadjuvant immunotherapy
  • anti-PD1/anti-PD-L1 and anti-CTLA4 agents

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Published Papers (1 paper)

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Research

13 pages, 1149 KiB  
Article
Adjuvant Use of Pembrolizumab for Stage III Melanoma in a Real-World Setting in Europe
by Michael Weichenthal, Joanna Mangana, Iva Gavrilova, Iwona Lugowska, Gergana Krumova Shalamanova, Lidija Kandolf, Vanna Chiarion-Sileni, Peter Mohr, Teodora Sotirova Karanikolova, Pawel Teterycz, Enrique Espinosa, Philipp Schnecko, Phil Cheng, Marc Bender, Shan Jiang, Thomas Burke, Paolo Antonio Ascierto, Helen Gogas, Ivan Marquez Rodas, Piotr Rutkowski, Dirk Schadendorf, Reinhard Dummer and for the EUMelaReg Consortiumadd Show full author list remove Hide full author list
Cancers 2024, 16(21), 3558; https://doi.org/10.3390/cancers16213558 - 22 Oct 2024
Cited by 1 | Viewed by 1261
Abstract
Background: Although data on patients treated with pembrolizumab are available from clinical trials and single-country real-world reports, to our knowledge no multi-country real-world studies have investigated the use of pembrolizumab as an adjuvant treatment for stage III melanoma. Methods: We used the European [...] Read more.
Background: Although data on patients treated with pembrolizumab are available from clinical trials and single-country real-world reports, to our knowledge no multi-country real-world studies have investigated the use of pembrolizumab as an adjuvant treatment for stage III melanoma. Methods: We used the European Melanoma Registry (EUMelaReg), a disease entity-based registry specific for melanoma, to examine treatment and outcomes for adult patients with stage III melanoma with lymph node involvement who had complete resection and received adjuvant treatment with pembrolizumab. The primary objectives were to describe the demographic and clinical characteristics of the included patients as well as time on adjuvant pembrolizumab treatment (TOT), real-world recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) from adjuvant pembrolizumab initiation. Secondary objectives were time to next treatment (TTNT) after adjuvant use of pembrolizumab, next-line therapy for stage III and unresectable stage IV melanoma and overall survival (OS) from initiation of pembrolizumab. Results: Patients were stratified according to age, sex, BRAF status, number of positive lymph nodes and disease substage. Median TOT was 11.1 (9.2–11.5) months, median RFS was 29.6 [18.7–not reached (NR)] months and median DMFS was 32.4 (22.7–NR) months. TTNT was 29.9 (22.2–NR) months, while median OS was not reached. Conclusions: The results of this study offer insights into the real-world use of pembrolizumab as an adjuvant therapy for melanoma in Europe. Full article
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