ER Stress and Gastrointestinal Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 429
Special Issue Editors
Interests: pancreatic cancer; clinical research; surgery; translational research; microenvironment
Special Issues, Collections and Topics in MDPI journals
Interests: pancreatic and hepatocellular carcinogenesis; stromal reaction; cancer-associated fibroblasts; inflammation; NASH; tumor metabolism especially lipid metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mitochondria and the endoplasmic reticulum (ER) are essential organelles in eukaryotic cells. They physically interact and are involved in the regulation of biologic functions, including mitochondrial respiration, bioenergetics, and apoptosis. The ER plays a central role in protein-folding and transport. Accumulation of unfolded proteins by, e.g., cellular redox regulation disturbances triggers an evolutionally conserved response, termed the unfolded protein response (UPR). Pathophysiological conditions like obesity can induce mitochondrial stress and trigger mitochondrial UPR. Defects in the mitochondrial UPR can result in ER stress and metabolic diseases, and sustained UPR can induce DNA damage and cancer. There is a strong association between ER stress, oxidative damage, and cancer. The aim of this Special Issue is to present recent findings and advances about the cross-talk between ER/mitochondrial stress, DNA/oxidative damage, and gastrointestinal diseases as original research and review articles.
Dr. Jörg Kleeff
Dr. Yoshiaki Sunami
Guest Editor
Manuscript Submission Information
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Keywords
- DNA damage
- oxidative damage
- ER stress
- mitochondrial stress
- metabolic diseases
- gastrointestinal diseases
